The combination of mTORC1/2 and PI3Kα inhibition alleviates PI3K pathway reactivation and leads to significant antitumor activity in multiple preclinical xenograft models.

被引：1
|
作者：
Brake, Rachael L. [1 ]
Fabrey, Robyn [2 ]
Szwaya, Jeff [1 ]
Fitzgerald, Michael [1 ]
Iartchouk, Natasha [1 ]
Guo, Xin [2 ]
Kuida, Keisuke [1 ]
Zohren, Fabian [1 ]
Manfredi, Mark [1 ]
机构：
[1] Takeda, Cambridge, MA USA
[2] Takeda Calif, San Diego, CA USA
来源：
MOLECULAR CANCER THERAPEUTICS | 2013年 / 12卷 / 11期
关键词：
D O I：
10.1158/1535-7163.TARG-13-C176
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
C176
引用
收藏
页数：1
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