Radiolabeled mAbs as Molecular Imaging and/or Therapy Agents Targeting PSMA

被引：12

作者：

Psimadas, Dimitrios ^{[1
]}

Valotassiou, Varvara ^{[1
]}

Alexiou, Sotiria ^{[1
]}

Tsougos, Ioannis ^{[1
]}

Georgoulias, Panagiotis ^{[1
]}

机构：

[1] Univ Thessaly, Sch Med, Univ Hosp Larissa, Dept Nucl Med, Larisa, Greece

来源：

CANCER INVESTIGATION | 2018年 / 36卷 / 02期

关键词：

Antibodies; radiolabeling; PSMA; prostate cancer; LU-177-PSMA-617 RADIOLIGAND THERAPY; METASTATIC PROSTATE-CANCER; MEMBRANE ANTIGEN PSMA; MONOCLONAL-ANTIBODY J591; IN-VIVO; PRECLINICAL EVALUATION; EXTRACELLULAR DOMAIN; RADIATION-DOSIMETRY; INHIBITORS; TUMORS;

D O I：

10.1080/07357907.2018.1430816

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Molecular imaging and therapy is a rapidly evolving field in research and clinical medicine. The use of the exciting and attractive properties of radioisotopes for imaging and therapy has made Nuclear Medicine very significant when it comes to molecular imaging/therapy. Monoclonal Antibodies (mAbs) on the other hand are very important targeting biomolecules with high affinity that can "carry" the radioisotope of choice. Herein we make a brief overview of the radiolabeled mAbs that target prostate specific membrane antigen (PSMA) and their use in the management of patients with prostate cancer (PCa).

引用

页码：118 / 128

页数：11

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