Photoredox-Catalzyed Halo-trifluoromethylation of 1,7-Enynes for Synthesis of 3,4-Dihydroquinolin-2(1H)-ones

被引：38

作者：

Yuan, Xin ^{[1
,2
]}

Zheng, Ming-Wei ^{[1
,2
]}

Di, Zhe-Chen ^{[1
]}

Cui, Yu-Sheng ^{[1
]}

Zhuang, Kai-Qiang ^{[1
]}

Qin, Long-Zhou ^{[1
]}

Fang, Zheng ^{[1
]}

Qiu, Jiang-Kai ^{[1
]}

Li, Guigen ^{[2
,3
]}

Guo, Kai ^{[1
]}

机构：

[1] Nanjing Tech Univ, Biotechnol & Pharmaceut Engn, Nanjing 211816, Jiangsu, Peoples R China

[2] Nanjing Univ, Inst Chem & Biomed Sci, Nanjing 210093, Jiangsu, Peoples R China

[3] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 08期

基金：

中国国家自然科学基金;

关键词：

photoredox; halo-trifluoromethylation; 1; 7-enynes; radical pathway; BENZENE-TETHERED 1,7-ENYNES; VISIBLE-LIGHT PHOTOCATALYSIS; RADICAL CYCLIZATION; BETA-AMINOPHOSPHONATES; CASCADE CYCLIZATION; CATALYSIS; PERFLUOROALKYLATION; FUNCTIONALIZATION; FLUORINATION; N-ENYNES;

D O I：

10.1002/adsc.201801681

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient photoredox-catalyzed halo-trifluoromethylation reaction of 1,7-enynes has been developed under mild conditions. This photocatalytic protocol provides an efficient and functional strategy leading to CF3- and halogen-containing 3,4-dihydroquinolin-2(1H)-ones from a wide range of 1,7-enynes through two different radical pathways. The reaction mechanism was proposed based on the control experiments.

引用

页码：1835 / 1845

页数：11

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