Panamonon A and B, a pair of novel tetrahydrobenzofuran derivatives from Litsea panamonja (Nees) Hook. f.

被引：8
|
作者：
Wang, Yun-Song [1 ]
Huang, Rong [1 ]
Li, Yan [2 ]
Shang, Wen-Bin [1 ]
Chen, Fei [1 ]
Zhang, Hong-Bin [1 ]
Yang, Jing-Hua [1 ]
机构：
[1] Yunnan Univ, Key Lab Med Chem Nat Resource, Minist Educ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China
[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2013年 / 6卷 / 01期
关键词：
Litsea panamonja (Nees) Hook. f; Lauraceae; Panamonon; Tetrahydrobenzofuran-2,5-dione; Homogentisic acid; ANTI-HIV AGENTS; VERTICILLATA; GLUTINOSA; ALKALOIDS; APORPHINE; ROB;
D O I：
10.1016/j.phytol.2012.10.008
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A pair of novel tetrahydrobenzofuran-2,5-dione derivatives with a unique C-18 carbon skeleton, panamonon A (1) and B (2), was isolated from the leaves and twigs of Litsea panamonja (Nees) Hook. f. These new compounds contain an unprecedented C-18 carbon skeleton consisting of a characteristic tetrahydrobenzofuran-2,5(3H,6H)-dione core with a biosynthetically extended geranyl side chain, designated as "panamonane". Their structures were elucidated by comprehensive spectroscopic analyses. A plausible biosynthetic pathway for 1 and 2 is discussed. The isolates were evaluated for cytotoxic activities against human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码：26 / 30
页数：5
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