In vitro and in vivo MRS study of human glioma metabolites

被引：0

作者：

Tugnoli, V

Tosi, MR

Barbarella, G

Ricci, R

Calbucci, F

Bertoluzza, A

机构：

[1] CNR,IST CITOMORFOL NORMALE & PATOL,I-40136 BOLOGNA,ITALY

[2] CNR,ICOCEA,AREA RIC,I-40129 BOLOGNA,ITALY

[3] UNIV BOLOGNA,OSPED BELLARIA,SERV NEURORADIOL,I-40139 BOLOGNA,ITALY

[4] UNIV BOLOGNA,OSPED BELLARIA,DIV NEUROCHIRURG,I-40139 BOLOGNA,ITALY

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 1997年 / 11卷 / 02期

关键词：

magnetic resonance spectroscopy; brain metabolites; gliomas;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study an in vitro multinuclear magnetic resonance spectroscopy (MRS) characterization of water soluble metabolites and of the lipid fraction obtained from 19 human gliomas (12 glioblastomas, 3 anaplastic astrocytomas, 2 anaplastic oligodendrogliomas and 2 oligodendrogliomas) with a total of 27 surgical specimens, is reported. Moreover, some in vivo H-1 MRS results are shown. The regional metabolic heterogeneity of glioblastomas, according to their morphological heterogeneity, is documented. For glioblastomas a specific in vitro H-1 MRS metabolite profile cannot be defined. Low and high grade oligodendrogliomas showed characteristic choline/creatine and alanine/creatine metabolite ratios. The spectroscopical characterization of histopathological factors concerning malignant gliomas is shown.

引用

页码：319 / 324

页数：6

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