In vitro and in vivo MRS study of human glioma metabolites

被引：0
|
作者：
Tugnoli, V
Tosi, MR
Barbarella, G
Ricci, R
Calbucci, F
Bertoluzza, A
机构：
[1] CNR,IST CITOMORFOL NORMALE & PATOL,I-40136 BOLOGNA,ITALY
[2] CNR,ICOCEA,AREA RIC,I-40129 BOLOGNA,ITALY
[3] UNIV BOLOGNA,OSPED BELLARIA,SERV NEURORADIOL,I-40139 BOLOGNA,ITALY
[4] UNIV BOLOGNA,OSPED BELLARIA,DIV NEUROCHIRURG,I-40139 BOLOGNA,ITALY
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 1997年 / 11卷 / 02期
关键词：
magnetic resonance spectroscopy; brain metabolites; gliomas;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this study an in vitro multinuclear magnetic resonance spectroscopy (MRS) characterization of water soluble metabolites and of the lipid fraction obtained from 19 human gliomas (12 glioblastomas, 3 anaplastic astrocytomas, 2 anaplastic oligodendrogliomas and 2 oligodendrogliomas) with a total of 27 surgical specimens, is reported. Moreover, some in vivo H-1 MRS results are shown. The regional metabolic heterogeneity of glioblastomas, according to their morphological heterogeneity, is documented. For glioblastomas a specific in vitro H-1 MRS metabolite profile cannot be defined. Low and high grade oligodendrogliomas showed characteristic choline/creatine and alanine/creatine metabolite ratios. The spectroscopical characterization of histopathological factors concerning malignant gliomas is shown.
引用
收藏
页码：319 / 324
页数：6
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