Graphene oxide: An efficient recyclable solid acid for the synthesis of bis(indolyl)methanes from aldehydes and indoles in water

被引：52
|
作者：
Wang, Yihong [1 ,2 ]
Sang, Rui [1 ,2 ]
Zheng, Yang [1 ,2 ]
Guo, Li [1 ,2 ]
Guan, Mei [3 ]
Wu, Yong [1 ,2 ]
机构：
[1] Sichuan Univ, Educ Minist, Key Lab Drug Targeting, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Sch Pharm, Dept Med Chem, Chengdu 610041, Peoples R China
[3] Sichuan Univ, West China Hosp, 37 GuoXue Rd, Chengdu 610041, Peoples R China
来源：
CATALYSIS COMMUNICATIONS | 2017年 / 89卷
基金：
中国国家自然科学基金;
关键词：
Graphene oxide; Bis(indolyl)methanes; Friedel-crafts reaction; Recyclable; Water; SOLVENT-FREE CONDITIONS; CATALYZED-REACTIONS; ORGANIC-SOLVENTS; FACILE SYNTHESIS; DERIVATIVES; DISPERSION; BISINDOLE; AGENTS;
D O I：
10.1016/j.catcom.2016.09.027
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
An efficient synthesis of bis(indolyl)methanes from aldehydes with indoles through graphene oxide-catalyzed Friedel-Crafts alkylation is developed. The reaction proceeds in water by using graphene oxide as the single catalyst to provide the desired products in good to excellent yields. Also, this methodology has a broad substrate scope, and is environment friendly and cost economic. (C) 2016 Published by Elsevier B.V.
引用
收藏
页码：138 / 142
页数：5
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