Emerging concepts for the in vitro derivation of murine haematopoietic stem and progenitor cells

被引：7
|
作者：
Garcia-Alegria, Eva [1 ]
Menegatti, Sara [1 ]
Batta, Kiran [2 ]
Cuvertino, Sara [1 ,3 ]
Florkowska, Magdalena [2 ]
Kouskoff, Valerie [1 ]
机构：
[1] Univ Manchester, Canc Res UK Manchester Inst, Canc Res UK Stem Cell Haematopoiesis Grp, Manchester, Lancs, England
[2] Univ Manchester, Canc Res UK Manchester Inst, Canc Res UK Stem Cell Biol Grp, Manchester, Lancs, England
[3] Univ Manchester, St Marys Hosp, Inst Human Dev, Manchester M13 9WL, Lancs, England
来源：
FEBS LETTERS | 2016年 / 590卷 / 22期
关键词：
bone marrow transplantation; embryonic stem cells; hemogenic endothelium; reprogramming; HEMOGENIC ENDOTHELIUM; YOLK-SAC; DEFINITIVE HEMATOPOIESIS; HAEMOGENIC ENDOTHELIUM; HUMAN FIBROBLASTS; ES CELLS; BLOOD PROGENITORS; PRIMITIVE STREAK; DEFINED FACTORS; NERVOUS-SYSTEM;
D O I：
10.1002/1873-3468.12300
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Well into the second decade of the 21st century, the field of regenerative medicine is bursting with hopes and promises to heal young and old. The bespoken generation of cells is thought to offer unprecedented cures for a vast range of diseases. Haematological disorders have already benefited tremendously from stem cell therapy in the form of bone marrow transplantation. However, lack of compatible donors often means that patients remain on transplantation waiting lists for too long. The in vitro derivation of haematopoietic stem cells offers the possibility to generate tailor-made cells for the treatment of these patients. Promising approaches to generate in vitro-derived blood progenitors include the directed differentiation of pluripotent stem cells and the reprogramming of somatic cells.
引用
收藏
页码：4116 / 4125
页数：10
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