Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells

被引：151

作者：

Laidlaw, Brian J. ^{[1
]}

Cui, Weiguo ^{[1
]}

Amezquita, Robert A. ^{[1
,2
]}

Gray, Simon M. ^{[1
]}

Guan, Tianxia ^{[1
]}

Lu, Yisi ^{[1
]}

Kobayashi, Yasushi ^{[1
]}

Flavell, Richard A. ^{[1
,2
]}

Kleinstein, Steven H. ^{[1
,3
,4
]}

Craft, Joe ^{[1
,5
]}

Kaech, Susan M. ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06510 USA

[2] Howard Hughes Med Inst, Chevy Chase, MD USA

[3] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA

[4] Yale Univ, Sch Med, Interdepartmental Program Computat Biol & Bioinfo, New Haven, CT 06510 USA

[5] Yale Univ, Sch Med, Dept Internal Med Rheumatol, New Haven, CT 06510 USA

来源：

NATURE IMMUNOLOGY | 2015年 / 16卷 / 08期

基金：

美国国家卫生研究院;

关键词：

PROTECTIVE IMMUNITY; DENDRITIC CELLS; EFFECTOR; INTERLEUKIN-10; EXPRESSION; RESPONSES; FOXP3(+); VIRUS; INFLAMMATION; LIPOPOLYSACCHARIDE;

D O I：

10.1038/ni.3224

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Memory CD8(+) T cells are critical for host defense upon reexposure to intracellular pathogens. We found that interleukin 10 (IL-10) derived from CD4(+) regulatory T cells (T-reg cells) was necessary for the maturation of memory CD8(+) T cells following acute infection with lymphocytic choriomeningitis virus (LCMV). Treg cell-derived IL-10 was most important during the resolution phase, calming inflammation and the activation state of dendritic cells. Adoptive transfer of IL-10-sufficient Treg cells during the resolution phase 'restored' the maturation of memory CD8(+) T cells in IL-10-deficient mice. Our data indicate that Treg cell-derived IL-10 is needed to insulate CD8(+) T cells from inflammatory signals, and reveal that the resolution phase of infection is a critical period that influences the quality and function of developing memory CD8(+) T cells.

引用

页码：871 / +

页数：11

共 50 条

[41] Suppression of antitumor immunity by IL-10 and TGF-β-producing T cells infiltrating the growing tumor:: Influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells
Jarnicki, Andrew G.
Lysaght, Joanne
Todryk, Stephen
Mills, Kingston H. G.
JOURNAL OF IMMUNOLOGY, 2006, 177 (02): : 896 - 904
[42] The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells
Hamilton, SE
Wolkers, MC
Schoenberger, SP
Jameson, SC
NATURE IMMUNOLOGY, 2006, 7 (05) : 475 - 481
[43] The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells
Sara E Hamilton
Monika C Wolkers
Stephen P Schoenberger
Stephen C Jameson
Nature Immunology, 2006, 7 : 475 - 481
[44] Different patterns of peripheral migration by memory CD4+ and CD8+ T cells
Thomas Gebhardt
Paul G. Whitney
Ali Zaid
Laura K. Mackay
Andrew G. Brooks
William R. Heath
Francis R. Carbone
Scott N. Mueller
Nature, 2011, 477 : 216 - 219
[45] IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells
Rosenberg, SA
Sportès, C
Ahmadzadeh, M
Fry, TJ
Ngo, LT
Schwarz, SL
Stetler-Stevenson, M
Morton, KE
Mavroukakis, SA
Morre, M
Buffet, R
Mackall, CL
Gress, RE
JOURNAL OF IMMUNOTHERAPY, 2006, 29 (03) : 313 - 319
[46] Cutting edge:: Lipopolysaccharide induces IL-10-producing regulatory CD4+ T cells that suppress the CD8+ T cell response
den Haan, Joke M. M.
Kraal, Georg
Bevan, Michael J.
JOURNAL OF IMMUNOLOGY, 2007, 178 (09): : 5429 - 5433
[47] Different patterns of peripheral migration by memory CD4+ and CD8+ T cells
Gebhardt, Thomas
Whitney, Paul G.
Zaid, Ali
Mackay, Laura K.
Brooks, Andrew G.
Heath, William R.
Carbone, Francis R.
Mueller, Scott N.
NATURE, 2011, 477 (7363) : 216 - U119
[48] Alefacept selectively reduces subpopulations of memory CD4+ and CD8+ T cells
Krueger, JG
Gilleaudeau, P
Kikuchi, T
Lee, E
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2002, 119 (03) : 759 - 759
[49] Memory CD8+ T cells in HIV infection
McMichael, AJ
Ogg, G
Wilson, J
Callan, MA
Hambleton, S
Appay, V
Kelleher, T
Rowland-Jones, S
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2000, 355 (1395) : 363 - 367
[50] IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients
Heo, Yu-Jung
Joo, Young-Bin
Oh, Hye-Jwa
Park, Mi-Kyung
Heo, Yang-Mi
Cho, Mi-La
Kwok, Seung-Ki
Ju, Ji-Hyeon
Park, Kyung-Su
Cho, Seok Goo
Park, Sung-Hwan
Kim, Ho-Youn
Min, Jun-Ki
IMMUNOLOGY LETTERS, 2010, 127 (02) : 150 - 156

← 1 2 3 4 5 →