miR-128 and its target genes in tumorigenesis and metastasis

被引：102
|
作者：
Li, Molin [1 ]
Fu, Weiming [2 ]
Wo, Lulu [1 ]
Shu, Xiaohong [1 ]
Liu, Fang [3 ]
Li, Chuangang [3 ]
机构：
[1] Dalian Med Univ, Dalian 116044, Peoples R China
[2] Chinese Acad Sci, Guangzhou Inst Adv Technol, Ctr Food Safety & Environm Technol, Guangzhou 511458, Guangdong, Peoples R China
[3] Dalian Med Univ, Affiliated Hosp 2, Dalian 116023, Peoples R China
来源：
EXPERIMENTAL CELL RESEARCH | 2013年 / 319卷 / 20期
关键词：
MicroRNA-128 (miR-128); Target genes; Tumorigenesis; Metastasis; MICRORNA EXPRESSION; GENOMIC REGIONS; MESSENGER-RNA; LUNG-CANCER; REVEALS; BMI-1; SIGNATURE; LEUKEMIA; RESISTANCE; MULTIPLE;
D O I：
10.1016/j.yexcr.2013.07.031
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNAs,(miRNAs) are a class of endogenous, non-coding, 18-24 nucleotide length single-strand RNAs that could modulate gene expression at post-transcriptional level. Previous studies have shown that miR-128 enriched in the brain plays an important role in the development of nervous system and the maintenance of normal physical functions. Aberrant expression of miR-128 has been detected in many types of human tumors and its validated target genes are involved in cancer-related biological processes such as cell proliferation, differentiation and apoptosis. In this review, we will summarize the roles of miR-128 and its target genes in tumorigenesis and metastasis. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：3059 / 3064
页数：6
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