Direct Lactonization of 2-Arylacetic Acids through Pd(II)-Catalyzed C-H Activation/C-O Formation

被引：73
|
作者：
Yang, Mingyu [1 ,2 ,3 ]
Jiang, Xingyu [1 ,2 ,3 ]
Shi, Wen-Juan [1 ,2 ,3 ]
Zhu, Qi-Lei [1 ,2 ,3 ]
Shi, Zhang-Jie [4 ]
机构：
[1] Peking Univ, BNLMS, Beijing 100871, Peoples R China
[2] Peking Univ, Coll Chem, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China
[3] Peking Univ, Green Chem Ctr, Beijing 100871, Peoples R China
[4] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 03期
关键词：
BOND FORMATION; PHENOLIC CONSTITUENTS; ARYLATION; ROUTE; DIBENZOFURANS; CYCLIZATION; REACTIVITY; SP(2); BARK;
D O I：
10.1021/ol303569b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium-catalyzed direct lactonization of 2-arylacetic acids through a reaction sequence that includes C-H activation/C-O formation is reported. This method provides a concise and efficient pathway to synthesize fully functionalized benzofuranone derivatives, which are highly relevant to bioactive natural and synthetic products.
引用
收藏
页码：690 / 693
页数：4
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