Identification of phosphorylation sites within the herpes simplex virus tegument protein VP22

被引：40

作者：

Elliot, G

O'Reilly, D

O'Hare, P

机构：

[1] Marie Curie Res Inst, Virus Assembly Grp, Surrey RH1 OTL, England

[2] Marie Curie Res Inst, Herpesvirus Grp, Surrey RH1 OTL, England

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 07期

关键词：

D O I：

10.1128/JVI.73.7.6203-6206.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The herpes simplex virus protein VP22 is a major phosphoprotein of infected cells. In this study, we identify two serine phosphorylation sites within VP22 and show that the W-terminal site is a substrate for casein kinase II, while the extreme C-terminal site is a substrate for another, as yet unidentified, cellular kinase. Furthermore, we show that a mutant of VP22 which has both sites altered is unable to incorporate phosphate in vivo, confirming that there are no other phosphorylation sites within VP22.

引用

页码：6203 / 6206

页数：4

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