AUY922, a novel HSP90 inhibitor: Final results of a First-in-human study in patients with advanced solid malignancies.

被引:23
|
作者
Samuel, T. A.
Sessa, C.
Britten, C.
Milligan, K. S.
Mita, M. M.
Banerji, U.
Pluard, T. J.
Stiegler, P.
Quad, C.
Shapiro, G.
机构
[1] Med Coll Georgia, Augusta, GA 30912 USA
[2] Osped Reg Bellinzona & Valli, Oncol Inst Southern Switzerland, Bellinzona, Switzerland
[3] Univ Calif Los Angeles, Clin Res Unit, Los Angeles, CA USA
[4] Nevada Canc Inst, Las Vegas, NV USA
[5] Canc Therapy & Res Ctr S Texas, San Antonio, TX 78229 USA
[6] Royal Marsden Hosp, Drug Dev Unit, Sutton, Surrey, England
[7] Washington Univ, Sch Med, Div Med Oncol, St Louis, MO USA
[8] Novartis Pharmaceut, E Hanover, NJ USA
[9] Novartis Pharmaceut, Basel, Switzerland
[10] Dana Farber Canc Inst, Boston, MA 02115 USA
关键词
D O I
10.1200/jco.2010.28.15_suppl.2528
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2528
引用
收藏
页数:1
相关论文
共 50 条
  • [41] Targeting HSP90 by the Novel Inhibitor NVP-AUY922 Reduces Growth and Angiogenesis of Pancreatic Cancer
    Moser, Christian
    Lang, Sven A.
    Hackl, Christina
    Wagner, Christine
    Scheiffert, Eva
    Schlitt, Hans J.
    Geissler, Edward K.
    Stoeltzing, Oliver
    ANTICANCER RESEARCH, 2012, 32 (07) : 2551 - 2561
  • [42] NVP-AUY922, a novel HSP90 inhibitor, inhibits the progression of malignant pheochromocytoma in vitro and in vivo
    Lian, Jianpo
    Lin, Dengqiang
    Xie, Xing
    Xu, Yunze
    Xu, Lieyu
    Meng, Li
    Zhu, Yu
    ONCOTARGETS AND THERAPY, 2017, 10 : 2219 - 2226
  • [43] HSP90 inhibitor AUY922 abrogates up-regulation of RTKs by mTOR inhibitor AZD8055 and potentiates its antiproliferative activity in human breast cancer
    Chen, Si-Meng
    Guo, Chen-Liang
    Shi, Jia-Jie
    Xu, Yi-Chao
    Chen, Yi
    Shen, Yan-Yan
    Su, Yi
    Ding, Jian
    Meng, Ling-Hua
    INTERNATIONAL JOURNAL OF CANCER, 2014, 135 (10) : 2462 - 2474
  • [44] Cassette dosing in tumor bearing animals for the discovery of NVP-AUY922, a novel HSP90 inhibitor
    Raynaud, Florence I.
    Hayes, Angela
    Martins, Vanessa
    Smith, Nicola F.
    Sharp, Swee Y.
    Valenti, Melanie
    Henley, Alan
    Matthews, Thomas P.
    Cheung, Kwai-Ming
    Kalusa, Andrew
    Jones, Keith
    James, Karen
    McDonald, Edward
    Brough, Paul A.
    Massey, Andrew
    Dymock, Brian
    Drysdale, Martin
    Eccles, Suzanne A.
    Workman, Paul
    MOLECULAR CANCER THERAPEUTICS, 2007, 6 (12) : 3524S - 3524S
  • [45] A Phase II Trial of AUY922, a Heat Shock Protein 90 (HSP90) Inhibitor, in ALK-Positive Lung Cancer Patients Previously Treated with ALK Inhibitors
    Gainor, Justin F.
    Marcoux, J. P.
    Rabin, Michael
    Gandhi, Leena
    Costa, Daniel B.
    Logan, Jennifer
    Jackman, David M.
    Shaw, Alice
    JOURNAL OF THORACIC ONCOLOGY, 2015, 10 (09) : S649 - S649
  • [46] Phase 2 Study of the HSP-90 Inhibitor AUY922 in Previously Treated and Molecularly Defined Patients with Advanced Non-Small Cell Lung Cancer
    Felip, Enriqueta
    Barlesi, Fabrice
    Besse, Benjamin
    Chu, Quincy
    Gandhi, Leena
    Kim, Sang-We
    Carcereny, Enric
    Sequist, Lecia V.
    Brunsvig, Paal
    Chouaid, Christos
    Smit, Egbert F.
    Groen, Harry J. M.
    Kim, Dong-Wan
    Park, Keunchil
    Avsar, Emin
    Szpakowski, Sebastian
    Akimov, Mikhail
    Garon, Edward B.
    JOURNAL OF THORACIC ONCOLOGY, 2018, 13 (04) : 576 - 584
  • [47] A HSP90 inhibitor, AUY922, is effective to overcome the MET- and AXL-mediated resistance to EGFR-TKI in lung cancer
    Rho, Jin Kyung
    Choi, Yun Jung
    Kime, Seon Y.
    So, Gwang Sup
    Choi, Se Hoon
    Choi, Chang-Min
    Lee, Jae Cheol
    CANCER RESEARCH, 2014, 74 (19)
  • [48] HSP90 inhibitor, AUY922, debilitates intrinsic and acquired lapatinib-resistant HER2-positive gastric cancer cells
    Park, Kang-Seo
    Hong, Yong Sang
    Choi, Junyoung
    Yoon, Shinkyo
    Kang, Jihoon
    Kim, Deokhoon
    Lee, Kang-Pa
    Im, Hyeon-Su
    Lee, Chang Hoon
    Seo, Seyoung
    Kim, Sang-We
    Lee, Dae Ho
    Park, Sook Ryun
    BMB REPORTS, 2018, 51 (12) : 660 - 665
  • [49] NVP-AUY922, a novel diarylisoxazole resorcinol HSP90 inhibitor, potently inhibits growth and metastasis of human tumor xenografts
    Eccles, Suzanne A.
    Sharp, Swee Y.
    Raynaud, Florence I.
    Valenti, Melanie
    Patterson, Lisa
    Gowan, Sharon
    Boxall, Kathy
    Aherne, Wynne
    Rowlands, Martin
    Hayes, Angela
    Martins, Vanessa
    Urban, Federique
    Prodromou, Chrisostomos
    Pearl, Laurence
    James, Karen
    Matthews, Thomas P.
    Cheung, Kwai-Ming
    Kalusa, Andrew
    Jones, Keith
    McDonald, Edward
    Brough, Paul A.
    Massey, Andrew
    Dymock, Brian
    Drysdale, Martin
    Workman, Paul
    MOLECULAR CANCER THERAPEUTICS, 2007, 6 (12) : 3522S - 3523S
  • [50] Antitumor Effect of Novel HSP90 Inhibitor NVP-AUY922 against Oral Squamous Cell Carcinoma
    Okui, Tatsuo
    Shimo, Tsuyoshi
    Hassan, Nur Mohammad Monsur
    Fukazawa, Takuya
    Kurio, Naito
    Takaoka, Munenori
    Naomoto, Yoshio
    Sasaki, Akira
    ANTICANCER RESEARCH, 2011, 31 (04) : 1197 - 1204