Cellular uptake and trafficking of polydiacetylene micelles

被引：32

作者：

Gravel, Edmond ^{[1
]}

Theze, Benoit ^{[2
,3
]}

Jacques, Isabelle ^{[2
,3
]}

Anilkumar, Parambath ^{[1
]}

Gombert, Karine ^{[2
,3
]}

Duconge, Frederic ^{[2
,3
]}

Doris, Eric ^{[1
]}

机构：

[1] CEA, IBiTecS, Serv Chim Bioorgan & Marquage, F-91191 Gif Sur Yvette, France

[2] Univ Paris Sud, BCEA, I2BM, Serv Hosp Frederic Joliot, F-91401 Orsay, France

[3] Univ Paris Sud, INSERM U1023, Lab Imagerie Mol Expt, F-91401 Orsay, France

来源：

NANOSCALE | 2013年 / 5卷 / 05期

关键词：

ENDOCYTOSIS; CAVEOLAE; PORTALS; ENTRY;

D O I：

10.1039/c2nr34149b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polydiacetylene (PDA) micelles coated with either carboxylate-, ammonium-, or methoxypolyethyleneglycol (PEG) chains were assembled and loaded with a fluorescent dye (DiO). Their interaction with MCF-7 human breast tumor cells was investigated by epi-fluorescence microscopy and fluorescence-activated cell sorting (FACS) to determine their internalization pathway and intracellular fate. It was found that the ionic character of the micelles influenced their internalization kinetics through a caveolae-mediated pathway and that all micelle types behaved somewhat similarly inside cells.

引用

页码：1955 / 1960

页数：6

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