Cellular uptake and trafficking of polydiacetylene micelles

被引：32
|
作者：
Gravel, Edmond [1 ]
Theze, Benoit [2 ,3 ]
Jacques, Isabelle [2 ,3 ]
Anilkumar, Parambath [1 ]
Gombert, Karine [2 ,3 ]
Duconge, Frederic [2 ,3 ]
Doris, Eric [1 ]
机构：
[1] CEA, IBiTecS, Serv Chim Bioorgan & Marquage, F-91191 Gif Sur Yvette, France
[2] Univ Paris Sud, BCEA, I2BM, Serv Hosp Frederic Joliot, F-91401 Orsay, France
[3] Univ Paris Sud, INSERM U1023, Lab Imagerie Mol Expt, F-91401 Orsay, France
来源：
NANOSCALE | 2013年 / 5卷 / 05期
关键词：
ENDOCYTOSIS; CAVEOLAE; PORTALS; ENTRY;
D O I：
10.1039/c2nr34149b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Polydiacetylene (PDA) micelles coated with either carboxylate-, ammonium-, or methoxypolyethyleneglycol (PEG) chains were assembled and loaded with a fluorescent dye (DiO). Their interaction with MCF-7 human breast tumor cells was investigated by epi-fluorescence microscopy and fluorescence-activated cell sorting (FACS) to determine their internalization pathway and intracellular fate. It was found that the ionic character of the micelles influenced their internalization kinetics through a caveolae-mediated pathway and that all micelle types behaved somewhat similarly inside cells.
引用
收藏
页码：1955 / 1960
页数：6
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