Effect of metoclopramide on muscle sympathetic nerve activity in humans

被引：4

作者：

Takeuchi, Y

Matsukawa, T

Sugiyama, Y

Iwase, S

Mano, T

机构：

[1] NAGOYA UNIV,ENVIRONM MED RES INST,DEPT AUTONOM & BEHAV NEUROSCI,DIV HIGHER NERVOUS CONTROL,NAGOYA,AICHI 46401,JAPAN

[2] NAGOYA UNIV,SCH MED,DEPT NEUROL,SHOWA KU,NAGOYA,AICHI 466,JAPAN

来源：

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM | 1996年 / 58卷 / 1-2期

关键词：

autonomic nervous system; cholinergic agonist; dopamine antagonist; metoclopramide; muscle sympathetic nerve activity;

D O I：

10.1016/0165-1838(95)00137-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of this study was to determine the effect of metoclopramide on the sympathetic nervous system. Muscle sympathetic nerve activity was increased in two stages after metoclopramide injection. The initial increase in sympathetic nerve activity may result from the unloading of arterial baroreceptors because there was a negative correlation between mean blood pressure and muscle sympathetic nerve activity. The later increase in muscle sympathetic nerve activity may be attributed to the central activation of the sympathetic nervous system because there was a positive correlation between mean blood pressure and muscle sympathetic nerve activity. These results suggest that metoclopramide activates the sympathetic nervous system by two different mechanisms.

引用

页码：115 / 120

页数：6

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