Paget's disease of bone: Diagnostic and therapeutic updates

被引：1
|
作者：
Alaya, R. [1 ]
Alaya, Z. [2 ]
Nang, M. [1 ]
Bouajina, E. [2 ]
机构：
[1] Ctr Hosp Sud Francilien, Serv Rhumatol, F-91100 Corbeil Essonnes, France
[2] Hop Farhat Hached, Serv Rhumatol, Ave Ibn El Jazzar, Sousse 4000, Tunisia
来源：
REVUE DE MEDECINE INTERNE | 2018年 / 39卷 / 03期
关键词：
Paget's disease of bone; SQSTM1; gene; Radiography; Bone fractures; Sarcomatous degeneration; Bisphosphonates; ZOLEDRONIC ACID; SINGLE INFUSION; PREVALENCE; MANAGEMENT; EPIDEMIOLOGY; SQSTM1; AGE;
D O I：
10.1016/j.revmed.2017.05.010
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Paget's disease of bone is the second most common metabolic bone disease after osteoporosis. Its pathogenesis is not yet clearly understood. Geographic distribution and epidemiological variations suggest a role of genetic and environmental factors in its pathophysiology. The frequency of the Paget's disease of bone increases with age. Its discovery can be fortuitous. Prognosis mainly depends on the occurrence of complications involving bones and joints, neurological, cardiovascular or metabolic systems. Treatment of symptomatic forms currently relies on bisphosphonates that have transformed its prognosis. (C) 2017 Societe Nationale Francaise de Medecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：185 / 191
页数：7
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