The role of pentraxin-3 as a prognostic biomarker in paraquat poisoning

Paraquat poisoning has been a public health problem in both the developing and developed countries. Pentraxin 3 is a member of the pentraxin family which is expressed as part of the acute-phase response that begins after injury, trauma, and infection. The aim of our study is to determine whether PTX3 levels can be a significant marker of pulmonary fibrosis and outcome of survival in paraquat poisoning. To measure the plasma paraquat level, we collected serum of the patients immediately after admission. EDTA plasma samples for checking the plasma PTX3 concentration were taken before and after the 1st hemoperfusion and after the 2nd hemoperfusion therapy. PTX3 concentrations in EDTA plasma were determined using a commercial solid-phase enzyme-linked immunosorbent assay (ELISA). Plasma paraquat concentration was higher in survivors than in non-survivors (p <0.05). Maximal plasma PTX3 level was significantly higher in the pulmonary fibrosis group, and plasma PTX3 was significantly increased throughout hemoperfusion therapy (p <0.01). Moreover, increase in PTX3 was greater in non-survivors than survivors (p < 0.05). Our results show that PTX3 is a useful biomarker of severity and outcome predictor in paraquat poisoning. (C) 2012 Elsevier Ireland Ltd. All rights reserved.