Let's look at cysts from both sides now

被引：9
|
作者：
Alper, Seth L. [1 ]
机构：
[1] Harvard Univ, Sch Med, Dept Med, Beth Israel Deaconess Med Ctr,Mol & Vasc Med Div, Boston, MA 02115 USA
来源：
KIDNEY INTERNATIONAL | 2008年 / 74卷 / 06期
关键词：
D O I：
10.1038/ki.2008.357
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
In the years since identification of autosomal-dominant polycystic kidney disease (ADPKD) genes, the lag time between initial understanding and translation to therapy has decreased rapidly. Albaqumi and colleagues describe a promising approach to slow ADPKD cyst enlargement through inhibition of the basolateral KCa3.1 K(+) channel, using a nontoxic small molecule with a close congener poised for rapid entry into the clinic. Cyst fluid accumulation can be blocked from both sides now.
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页码：699 / 702
页数：5
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