Let's look at cysts from both sides now

被引：9

作者：

Alper, Seth L. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Med, Beth Israel Deaconess Med Ctr,Mol & Vasc Med Div, Boston, MA 02115 USA

来源：

KIDNEY INTERNATIONAL | 2008年 / 74卷 / 06期

关键词：

D O I：

10.1038/ki.2008.357

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In the years since identification of autosomal-dominant polycystic kidney disease (ADPKD) genes, the lag time between initial understanding and translation to therapy has decreased rapidly. Albaqumi and colleagues describe a promising approach to slow ADPKD cyst enlargement through inhibition of the basolateral KCa3.1 K(+) channel, using a nontoxic small molecule with a close congener poised for rapid entry into the clinic. Cyst fluid accumulation can be blocked from both sides now.

引用

页码：699 / 702

页数：5

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