Fecal microbiota transplantation in gastrointestinal and extraintestinal disorders

被引：24

作者：

Ianiro, Gianluca ^{[1
]}

Segal, Jonathan P. ^{[2
]}

Mullish, Benjamin H. ^{[3
]}

Quraishi, Mohammed N. ^{[4
,5
]}

Porcari, Serena ^{[1
]}

Fabiani, Ginevra ^{[1
]}

Gasbarrini, Antonio ^{[1
]}

Cammarota, Giovanni ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Digest Dis Ctr, Fdn Policlin Univ Agostino Gemelli IRCCS, Rome, Italy

[2] St Marys Hosp, Dept Gastroenterol, London, England

[3] Imperial Coll London, Div Digest Dis, Dept Metab Digest & Reprod, Fac Med, London, England

[4] Univ Birmingham, Microbiome Treatment Ctr, Birmingham, W Midlands, England

[5] Univ Hosp Birmingham NHS Fdn Trust, Dept Gastroenterol, Birmingham, W Midlands, England

来源：

FUTURE MICROBIOLOGY | 2020年 / 15卷 / 12期

关键词：

cancer; Clostridium difficile; fecal microbiota transplantation; inflammatory bowel disease; irritable bowel syndrome; metabolic syndrome; microbiome; microbiota; CLOSTRIDIUM-DIFFICILE INFECTION; ACTIVE ULCERATIVE-COLITIS; INTESTINAL MICROBIOTA; INSULIN SENSITIVITY; RECURRENT; REMISSION; EFFICACY; METAANALYSIS; MANAGEMENT; INDUCTION;

D O I：

10.2217/fmb-2020-0061

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fecal microbiota transplantation (FMT) is the infusion of feces from a healthy donor into the gut of a recipient to treat a dysbiosis-related disease. FMT has been proven to be a safe and effective treatment forClostridioides difficileinfection, but increasing evidence supports the role of FMT in other gastrointestinal and extraintestinal diseases. The aim of this review is to paint the landscape of current evidence of FMT in different fields of application (including irritable bowel syndrome, inflammatory bowel disease, liver disorders, decolonization of multidrug-resistant bacteria, metabolic disorders and neurological disorders), as well as to discuss the current regulatory scenario of FMT, and hypothesize future directions of FMT.

引用

页码：1173 / 1184

页数：12

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