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The Brazilian version of the Neuropsychiatric Inventory-Clinician rating scale (NPI-C): reliability and validity in dementia
被引:20
|作者:
Stella, Florindo
[1
,2
]
Forlenza, Orestes Vicente
[2
]
Laks, Jerson
[3
]
de Andrade, Larissa Pires
[1
]
Ljubetic Avendano, Michelle A.
[2
]
Gasparetto Se, Elisandra Villela
[4
]
Cacao, Joao de Castilho
[5
]
Lyketsos, Constantine G.
[6
]
de Medeiros, Kate
[7
]
机构:
[1] Univ Estadual Paulista UNESP, Biosci Inst, BR-13506900 Rio Claro, SP, Brazil
[2] Univ Sao Paulo, Fac Med, Dept & Inst Psychiat, Lab Neurosci LIM 27, BR-05508 Sao Paulo, Brazil
[3] Univ Fed Rio de Janeiro, Inst Psychiat, Ctr Alzheimers Dis & Related Disorders, BR-21941 Rio De Janeiro, RJ, Brazil
[4] Univ Estadual Campinas, Fac Med, Clin Geriatr Psychiat, Campinas, SP, Brazil
[5] FAMERP Fac Med, Geriatr Unity, Sao Jose Do Rio Preto, Brazil
[6] Johns Hopkins Univ, Dept Psychiat, Johns Hopkins Bayview, Baltimore, MD USA
[7] Miami Univ, Dept Sociol & Gerontol, Oxford, OH 45056 USA
基金:
巴西圣保罗研究基金会;
关键词:
neuropsychiatric symptoms;
dementia;
Alzheimer's disease;
scale;
neuropsychiatric assessment;
Brazil;
ALZHEIMERS-DISEASE;
SYMPTOMS;
DEPRESSION;
APATHY;
IMPAIRMENT;
PREVALENCE;
D O I:
10.1017/S1041610213000811
中图分类号:
B849 [应用心理学];
学科分类号:
040203 ;
摘要:
Background: Patients with dementia may be unable to describe their symptoms, and caregivers frequently suffer emotional burden that can interfere with judgment of the patient's behavior. The Neuropsychiatric Inventory-Clinician rating scale (NPI-C) was therefore developed as a comprehensive and versatile instrument to assess and accurately measure neuropsychiatric symptoms (NPS) in dementia, thereby using information from caregiver and patient interviews, and any other relevant available data. The present study is a follow-up to the original, cross-national NPI-C validation, evaluating the reliability and concurrent validity of the NPI-C in quantifying psychopathological symptoms in dementia in a large Brazilian cohort. Methods: Two blinded raters evaluated 312 participants (156 patient-knowledgeable informant dyads) using the NPI-C for a total of 624 observations in five Brazilian centers. Inter-rater reliability was determined through intraclass correlation coefficients for the NPI-C domains and the traditional NPI. Convergent validity included correlations of specific domains of the NPI-C with the Brief Psychiatric Rating Scale (BPRS), the Cohen-Mansfield Agitation Index (CMAI), the Cornell Scale for Depression in Dementia (CSDD), and the Apathy Inventory (AI). Results: Inter-rater reliability was strong for all NPI-C domains. There were high correlations between NPI-C/delusions and BPRS, NPI-C/apathy-indifference with the AI, NPI-C/depression-dysphoria with the CSDD, NPI-C/agitation with the CMAI, and NPI-C/aggression with the CMAI. There was moderate correlation between the NPI-C/aberrant vocalizations and CMAI and the NPI-C/hallucinations with the BPRS. Conclusion: The NPI-C is a comprehensive tool that provides accurate measurement of NPS in dementia with high concurrent validity and inter-rater reliability in the Brazilian setting. In addition to universal assessment, the NPI-C can be completed by individual domains.
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页码:1503 / 1511
页数:9
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