Identification of caffeoylquinic acid derivatives as natural protein tyrosine phosphatase 1B inhibitors from Artemisia princeps

被引：21
|
作者：
Zhang, Jie [1 ,2 ]
Sasaki, Tatsunori [2 ]
Li, Wei [2 ,3 ]
Nagata, Kazuya [2 ]
Higai, Koji [2 ]
Feng, Feng [1 ]
Wang, Jian [3 ]
Cheng, Maosheng [3 ]
Koike, Kazuo [2 ]
机构：
[1] China Pharmaceut Univ, Dept Nat Med Chem, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China
[2] Toho Univ, Fac Pharmaceut Sci, Miyama 2-2-1, Funabashi, Chiba 2748510, Japan
[3] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2018年 / 28卷 / 07期
基金：
中国国家自然科学基金;
关键词：
Protein tyrosine phosphatase 1B; Caffeoylquinic acid; Chlorogenic acid; Artemisia princeps; LIQUID-CHROMATOGRAPHY; PHENOLIC-COMPOUNDS; AERIAL PARTS; PTP1B; FLAVONOIDS; DISCOVERY; EUPATILIN; OBESITY; AGENT; MICE;
D O I：
10.1016/j.bmcl.2018.02.052
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Considerable attention has been paid to protein tyrosine phosphatase 1B (PTP1B) inhibitors as a potential therapy for diabetes, obesity, and cancer. Ten caffeoylquinic acid derivatives (1-10) from leaves of Artemisia princeps Pamp. (Asteraceae) were identified as natural PTP1B inhibitors. Among them, chlorogenic acid (3) showed the most potent inhibitory activity (IC50 11.1 mu M). Compound 3 was demonstrated to be a noncompetitive inhibitor by a kinetic analysis. Molecular docking simulation suggested that compound 3 bound to the allosteric site of PTP1B. Furthermore, compound 3 showed remarkable selectivity against four homologous PTPs. According to these findings, compound 3 might be potentially valuable for further drug development. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1194 / 1197
页数：4
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