Association of Caspase-8 Genotypes With the Risk for Nasopharyngeal Carcinoma in Taiwan

被引：6

作者：

Shih, Liang-Chun ^{[1
,2
,3
]}

Tsai, Chia-Wen ^{[1
,3
]}

Chang, Wen-Shin ^{[1
,3
]}

Shen, Te-Chun ^{[3
]}

Wang, Yun-Chi ^{[1
,3
]}

Yang, Jia-Sing ^{[3
,4
]}

Lin, Meng-Liang ^{[5
]}

Wang, Zhi-Hong ^{[6
]}

Bau, Da-Tian ^{[1
,3
,7
]}

机构：

[1] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan

[2] China Med Univ Hosp, Dept Otorhinolaryngol, Taichung, Taiwan

[3] China Med Univ Hosp, Dept Med Res, Terry Fox Canc Res Lab, 2 Yuh Der Rd, Taichung 404, Taiwan

[4] China Med Univ Hosp, Dept Med Res, Taichung, Taiwan

[5] China Med Univ, Dept Med Lab Sci & Biotechnol, Taichung, Taiwan

[6] Asia Univ, Dept Food Nutr & Hlth Biotechnol, Taichung, Taiwan

[7] Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan

来源：

ANTICANCER RESEARCH | 2020年 / 40卷 / 10期

关键词：

Case-control study; caspase-8; genotype; nasopharyngeal; carcinoma; polymorphism; Taiwan; 6N DEL POLYMORPHISM; PROMOTER POLYMORPHISM; D302H POLYMORPHISMS; CANCER-RISK; ORAL-CANCER; APOPTOSIS; CASP8; SUSCEPTIBILITY; METAANALYSIS; MUTATIONS;

D O I：

10.21873/anticanres.14562

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Accumulating evidence shows that caspase-8 (Cas-8) rs3834129 genotypes determine susceptibility to various cancers, but their association with nasopharyngeal carcinoma (NPC) has not been examined. We aimed at investigating the association of Cas-8 rs3834129 with NPC risk. Materials and Methods: Cas-8 rs3834129 genotypes and their associations with NPC risk were investigated among 176 NPC patients and 352 non-cancer subjects by the PCR-RFLP method. Additionally, the interaction of Cas-8 rs3834129 genotypes with smoking was examined. Results: The II, ID and DD frequencies were 56.8, 36.9 and 6.3% among NPC patients and 54.8, 38.1 and 7.1% among control subjects (p(trend)=0.8830). Allelic frequency distribution analysis also indicated that the D allele is not a risk factor for NPC (p=0.6183). There was no interaction between Cas-8 rs3834129 and smoking and NPC risk (p=0.8305). Conclusion: Cas-8 rs3834129 genotypes play a minor role in the risk for NPC.

引用

页码：5503 / 5508

页数：6

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