Clinical and Electroencephalographic (EEG) Features Associated With Refractoriness in Benign Childhood Epilepsy With Centrotemporal Spikes

被引:4
|
作者
Xiao, Fenglai [1 ]
An, Dongmei [1 ]
Chen, Sihan [1 ]
Ren, Jiechuan [1 ]
Zhou, Dong [1 ]
机构
[1] Sichuan Univ, West China Hosp, Dept Neurol, Chengdu 610041, Sichuan, Peoples R China
基金
中国国家自然科学基金;
关键词
benign childhood epilepsy with centrotemporal spikes; clinical and electroencephalographic features; antiepileptic drugs; risk factor; refractoriness; ROLANDIC EPILEPSY; CONVULSIVE EPILEPSY; CHILDREN; LOCALIZATION; COMMUNITY; SEIZURES; ONSET; BECTS;
D O I
10.1177/0883073815575367
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The aim of this study is to identify clinical or electroencephalographic (EEG) features associated with refractoriness to the initial antiepileptic drug in typical benign childhood epilepsy with centrotemporal spikes. A total of 87 children with typical benign childhood epilepsy with centrotemporal spikes were retrospectively reviewed in the analyses. The patients were subdivided into 2 groups: patients whose seizures were controlled with monotherapy and patients requiring 2 medications. Sixty-three children achieved seizure freedom with monotherapy, whereas 24 received 2 medications for seizure control. Diffusing foci at the follow-up EEG and delayed treatment (duration >1 year) are 2 main risk factors associated with more refractory cases (P < .001). Delayed diagnosis (37.1%) and nonadherence to treatment (57.2%) contributed to delayed treatment. Our findings suggested that diffusing foci on EEG and delayed treatment are associated with more frequent seizures and refractoriness in benign childhood epilepsy with centrotemporal spikes. Diagnostic delays and nonadherence hindered timely care, which may represent opportunities for improved intervention.
引用
收藏
页码:1591 / 1597
页数:7
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