Small molecule interleukin-8 modulators

被引：13

作者：

Li, JJ ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Dept Chem, Ann Arbor, MI 48105 USA

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2001年 / 11卷 / 12期

关键词：

chemokines (cytokines); CXCR1; CXCR2; IL-8; inflammation; p38; kinase;

D O I：

10.1517/13543776.11.12.1905

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The correlation between the production of IL-8, along with many chemokines and inflammatory diseases, has been well documented. Therefore, modulation of IL-8 production is a viable approach to drug discovery for the treament of inflammatory diseases. Two general approaches to regulate IL-8 production are most prevalent. One is direct inhibition of IL-8 receptors, CXCR1 and/or CXCR2. The other is downstream regulation of IL-8 production via inhibition of p38 kinase. This review accounts the patent literature published between 1998 and 2001, covering small molecule IL-8 modulators using both approaches.

引用

页码：1905 / 1910

页数：6

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