hOGG1 C1245G gene polymorphism associated with prostate cancer: a meta-analysis

被引:5
|
作者
Chen, Yang [1 ,2 ,3 ,4 ]
Li, Jie [1 ,2 ,3 ,4 ]
Li, Tianyu [1 ,2 ,3 ,4 ]
Mo, Zengnan [1 ,2 ,3 ,4 ]
机构
[1] Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning 530021, Guangxi Zhuang, Peoples R China
[2] Guangxi Med Univ, Affiliated Hosp 1, Dept Urol & Nephrol, Nanning 530021, Guangxi Zhuang, Peoples R China
[3] Guangxi Med Univ, Guangxi Key Lab Genom & Personalized Med, Nanning 530021, Guangxi Zhuang, Peoples R China
[4] Guangxi Med Univ, Guangxi Collaborat Innovat Ctr Genom & Personaliz, Nanning 530021, Guangxi Zhuang, Peoples R China
来源
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS | 2015年 / 30卷 / 02期
关键词
hOGG1; Human oxoguanine glycosylase 1; Polymorphism; Prostate cancer; EXCISION-REPAIR GENES; SER326CYS POLYMORPHISM; BASE-EXCISION; BLADDER-CANCER; RISK; STATISTICS; CHINESE; SUSCEPTIBILITY; XPD; 8-HYDROXYGUANINE;
D O I
10.5301/jbm.5000144
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Background: Prostate cancer (Pca) is one of the most frequently encountered multifactorial malignant diseases worldwide. The human oxoguanine glycosylase 1 (hOGG1) C1245G polymorphism (rs1052133) has been found to be associated with Pca. However, the conclusions have been controversial. Methods: Based on the PubMed, Embase, HuGENet and Chinese National Knowledge Infrastructure (CNKI) databases, this meta-analysis was conducted with 4 models. Eleven qualified studies were included. Results: Although no positive relation was discovered in the pooled analysis, significant associations between rs1052133 and Pca were found in the Asian population (recessive: odds ratio [OR] = 1.580, 95% confidence interval [95% CI], 1.189-2.098; GG vs. GC: OR = 1.504, 95% CI, 1.114-2.030; GG vs. CC: OR = 1.677, 95% CI, 1.201-2.342; allele analysis: OR = 1.249, 95% CI, 1.077-1.449), whites (dominant: OR = 2.138, 95% CI, 1.483-3.083; recessive: OR = 3.143, 95% CI, 1.171-8.437; GG vs. CC: OR = 3.992, 95% CI, 1.891-8.431; allele analysis: OR = 1.947, 95% CI, 1.467-2.586) and mixed populations (recessive: OR = 0.636, 95% CI, 0.484-0.834; GG vs. GC: OR = 0.654, 95% CI, 0.492-0.871; GG vs. CC: OR = 0.624, 95% CI, 0.473-0.823; allele analysis: OR = 0.857, 95% CI, 0.771-0.954). After excluding studies deviating from the Hardy-Weinberg equilibrium, a significant association was also found in the same ethnic groups. In addition, a new positive relation was identified in the "other country" subgroup (with China, South Korea and Australia included) (dominant: OR = 1.622, 95% CI, 1.163-2.261; recessive: OR = 1.773, 95% CI, 1.308-2.404; GG vs. GC: OR = 1.614, 95% CI, 1.169-2.230; GG vs. CC: OR = 2.108, 95% CI, 1.456-3.051; allele analysis: OR = 1.494, 95% CI, 1.235-1.808) and among the Chinese-Korean population. Conclusions: In conclusion, we suggest that the hOGG1 C1245G polymorphism might be potentially associated with Pca risk in different ethnicities and countries, especially among Asians. Further studies are needed to confirm these relations.
引用
收藏
页码:E161 / E168
页数:8
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