Serum procalcitonin in the diagnosis and management of intra-abdominal infections

被引：5

作者：

Watkins, Richard R. ^{[1
,2
]}

Lemonovich, Tracy L. ^{[3
]}

机构：

[1] Akron Gen Med Ctr, Div Infect Dis, Akron, OH 44302 USA

[2] NE Ohio Med Univ, Dept Med, Rootstown, OH USA

[3] Univ Hosp Case Med Ctr, Div Infect Dis & HIV Med, Cleveland, OH USA

来源：

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | 2012年 / 10卷 / 02期

关键词：

antibiotic therapy; appendicitis; liver transplantation; pancreatitis; peritonitis; procalcitonin; sepsis; C-REACTIVE PROTEIN; SPONTANEOUS BACTERIAL PERITONITIS; ANTI-THYMOCYTE GLOBULIN; CRITICALLY-ILL PATIENTS; ANTIBIOTIC-THERAPY; PLASMA PROCALCITONIN; ACUTE APPENDICITIS; DISEASES SOCIETY; SEPSIS; MARKER;

D O I：

10.1586/ERI.11.164

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The biomarker procalcitonin (PCT) has been used to diagnose and monitor a number of clinically significant infections. Serum levels of PCT are often increased in the presence of bacterial and fungal infections but not viral infections or noninfectious inflammation. Intra-abdominal infections (IAIs) are serious conditions that pose difficult challenges to physicians and the healthcare system. Researchers have evaluated PCT in the management of IAIs, both for diagnosis and for guiding antibiotic therapy. The studies have produced mixed results, leading to controversy on the utility of PCT in IAIs. PCT appears to be most useful in diagnosing postoperative infections and necrotizing pancreatitis. This review aims to summarize these data, explore the pathophysiology of PCT in sepsis from IAIs, discuss the strengths and weaknesses of PCT monitoring in IAIs, and provide guidance for the interpretation of PCT levels.

引用

页码：197 / 205

页数：9

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