Protein tyrosine phosphatase 1B: A potential leptin resistance factor of obesity

被引：64

作者：

Cook, WS ^{[1
]}

Unger, RH

机构：

[1] Univ Texas, SW Med Ctr, Dept Internal Med, Touchstone Ctr Diabet Res,Gifford Labs, Dallas, TX 75390 USA

[2] Vet Affairs Med Ctr, Dallas, TX 75216 USA

来源：

DEVELOPMENTAL CELL | 2002年 / 2卷 / 04期

关键词：

D O I：

10.1016/S1534-5807(02)00158-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Indirect evidence implicates leptin resistance in the pathogenesis of the lipotoxicity that complicates obesity and results in the metabolic syndrome. In this issue of Developmental Cell, two groups identify protein tyrosine phosphatase 1B (PTP1B) as a cause of leptin resistance through dephosphorylation of Jak2.

引用

页码：385 / 387

页数：3

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