BIOSYNTHESIS A sulfonate relay revealed

被引：3
|
作者：
Van Lanen, Steven G. [1 ]
机构：
[1] Univ Kentucky, Coll Pharm, Dept Pharmaceut Sci, Lexington, KY 40536 USA
来源：
NATURE CHEMICAL BIOLOGY | 2013年 / 9卷 / 10期
关键词：
ANTIBIOTIC BIOSYNTHESIS; ARYL SULFOTRANSFERASE; SULFATION;
D O I：
10.1038/nchembio.1319
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Biological sulfonate incorporation is mediated by 3'-phosphoadenosine-5'-phosphosulfate-dependent sulfotransferases and, to a lesser extent, arylsulfate sulfotransferases. An unusual two-enzyme strategy for sulfonate mobilization involving both types of sulfotransferases has been revealed during antibiotic biosynthesis, which uses a new polyketide as the sulfonate shuttle.
引用
收藏
页码：602 / 603
页数：2
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