Downstream from calcium signalling: mitochondria, vacuoles and pancreatic acinar cell damage

被引：6

作者：

Voronina, S. ^{[1
]}

Sherwood, M. ^{[1
]}

Barrow, S. ^{[1
]}

Dolman, N. ^{[1
]}

Conant, A. ^{[1
]}

Tepikin, A. ^{[1
]}

机构：

[1] Univ Liverpool, Physiol Lab, Liverpool L69 3BX, Merseyside, England

来源：

ACTA PHYSIOLOGICA | 2009年 / 195卷 / 01期

关键词：

ATP; calcium signalling; endosomes; mitochondria; pancreatitis; vacuoles; PREMATURE PROTEASE ACTIVATION; CERULEIN-INDUCED PANCREATITIS; CYTOSOLIC CA2+ SIGNALS; BILE-ACIDS INDUCE; INOSITOL TRISPHOSPHATE; ENDOPLASMIC-RETICULUM; RYANODINE-RECEPTORS; EXOCRINE PANCREAS; POLARIZED CELLS; GLAND-CELLS;

D O I：

10.1111/j.1748-1716.2008.01931.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Ca2+ is one of the most ancient and ubiquitous second messengers. Highly polarized pancreatic acinar cells serve as an important cellular model for studies of Ca2+ signalling and homeostasis. Downstream effects of Ca2+ signalling have been and continue to be an important research avenue. The primary functions regulated by Ca2+ in pancreatic acinar cells - exocytotic secretion and fluid secretion - have been defined and extensively characterized in the second part of the last century. The role of cytosolic Ca2+ in cellular pathology and the related question of the interplay between Ca2+ signalling and bioenergetics are important current research lines in our and other laboratories. Recent findings in these interwoven research areas are discussed in the current review.

引用

页码：161 / 169

页数：9

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