Downstream from calcium signalling: mitochondria, vacuoles and pancreatic acinar cell damage

被引：6

作者：

Voronina, S. ^{[1
]}

Sherwood, M. ^{[1
]}

Barrow, S. ^{[1
]}

Dolman, N. ^{[1
]}

Conant, A. ^{[1
]}

Tepikin, A. ^{[1
]}

机构：

[1] Univ Liverpool, Physiol Lab, Liverpool L69 3BX, Merseyside, England

来源：

ACTA PHYSIOLOGICA | 2009年 / 195卷 / 01期

关键词：

ATP; calcium signalling; endosomes; mitochondria; pancreatitis; vacuoles; PREMATURE PROTEASE ACTIVATION; CERULEIN-INDUCED PANCREATITIS; CYTOSOLIC CA2+ SIGNALS; BILE-ACIDS INDUCE; INOSITOL TRISPHOSPHATE; ENDOPLASMIC-RETICULUM; RYANODINE-RECEPTORS; EXOCRINE PANCREAS; POLARIZED CELLS; GLAND-CELLS;

D O I：

10.1111/j.1748-1716.2008.01931.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Ca2+ is one of the most ancient and ubiquitous second messengers. Highly polarized pancreatic acinar cells serve as an important cellular model for studies of Ca2+ signalling and homeostasis. Downstream effects of Ca2+ signalling have been and continue to be an important research avenue. The primary functions regulated by Ca2+ in pancreatic acinar cells - exocytotic secretion and fluid secretion - have been defined and extensively characterized in the second part of the last century. The role of cytosolic Ca2+ in cellular pathology and the related question of the interplay between Ca2+ signalling and bioenergetics are important current research lines in our and other laboratories. Recent findings in these interwoven research areas are discussed in the current review.

引用

页码：161 / 169

页数：9

共 50 条

[1] A mathematical model of intricate calcium dynamics and modulation of calcium signalling by mitochondria in pancreatic acinar cells
Manhas, Neeraj
Anbazhagan, N.
CHAOS SOLITONS & FRACTALS, 2021, 145
[2] Mitochondria and calcium: from cell signalling to cell death
Duchen, MR
JOURNAL OF PHYSIOLOGY-LONDON, 2000, 529 (01): : 57 - 68
[3] Calcium Signalling Pathology Modelling pancreatic acinar cells
Jhariya, D. C.
Mullai, V. R.
Jadav, Ravindra
Mullasseri, Sileesh
Yennamalli, Ragothaman M.
Udham, Atig
Karthic, A.
CURRENT SCIENCE, 2024, 127 (07): : 779 - 780
[4] Intracellular pH and calcium signalling in rat pancreatic acinar cells
Gonzalez, A
Pariente, JA
Salido, GM
Camello, PJ
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1997, 434 (05): : 609 - 614
[5] Intracellular pH and calcium signalling in rat pancreatic acinar cells
A. Gonzalez
J. A. Pariente
G. M. Salido
P. J. Camello
Pflügers Archiv, 1997, 434 : 609 - 614
[6] Low Extracellular pH Induces Damage in the Pancreatic Acinar Cell by Enhancing Calcium Signaling
Reed, Anamika M.
Husain, Sohail Z.
Thrower, Edwin
Alexandre, Martine
Shah, Ahsan
Gorelick, Fred S.
Nathanson, Michael H.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (03) : 1919 - 1926
[7] ROLE OF CALCIUM IN PANCREATIC ACINAR CELL SECRETION
SUNG, CK
WILLIAMS, JA
MINERAL AND ELECTROLYTE METABOLISM, 1988, 14 (01) : 71 - 77
[8] The stability of traveling calcium pulses in a pancreatic acinar cell
Romeo, MM
Jones, CKRT
PHYSICA D-NONLINEAR PHENOMENA, 2003, 177 (1-4) : 242 - 258
[9] Mitochondria are involved in confining local calcium spikes in mouse pancreatic acinar cells
Tinel, H
Mogami, H
Cancela, JM
Tepikin, AV
Petersen, OH
JOURNAL OF GENERAL PHYSIOLOGY, 1999, 114 (01): : 13A - 13A
[10] Regulation of early response genes in pancreatic acinar cells: external calcium and nuclear calcium signalling aspects
Fedirko, N.
Gerasimenko, J. V.
Tepikin, A. V.
Gerasimenko, O. V.
ACTA PHYSIOLOGICA, 2009, 195 (01) : 51 - 60

← 1 2 3 4 5 →