Expression of TAp73 and ΔNp73 isoform transcripts in thyroid tumours

被引：13
|
作者：
Ferru, A
Denis, S
Guilhot, J
Gibelin, H
Tourani, JM
Kraimps, JL
Larsen, CJ
Karayan-Tapon, L
机构：
[1] PBS, EA3805, Mol Oncol Lab, F-86021 Poitiers, France
[2] CHU La Miletrie, Med Oncol Serv, F-86021 Poitiers, France
[3] CHU La Miletrie, Ctr Rech Clin, F-86021 Poitiers, France
[4] CHU La Miletrie, Serv Chirurg Viscerale & Endocrinienne, F-86021 Poitiers, France
来源：
EJSO | 2006年 / 32卷 / 02期
关键词：
thyroid; carcinoma; transcripts; TAp73; Delta Np73;
D O I：
10.1016/j.ejso.2005.09.014
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: This study was aimed to determine p73 status in thyroid tumours. Methods: Differential expression of the TAp73, Delta TAp73 transcripts was measured in a panel of 60 thyroid malignancies by quantitative RTPCR. Results: By comparison to normal thyroid tissue surrounding the tumours, we observed significant downregulation of TP73 transcripts in adenomas and in differentiated carcinomas. Correlations were found in normal tissue specimens between the expression of TAp73 and Delta Np73 transcripts and that of p53, p14(ARF) p16(INK4a), but these correlations were lost in carcinomas (PTC or FTC). Conclusions: We have found significant variations of TAp73, Delta Np73, p53, p14(ARF) p16(INK4a), expressions and correlations between the expressions of those different genes in thyroid cancer. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：228 / 230
页数：3
相关论文
共 50 条
  • [31] Differential control of TAp73 and ΔNp73 protein stability by the ring finger ubiquitin ligase PIR2
    Sayan, Berna S.
    Yang, Ai Li
    Conforti, Franco
    Tucci, Paola
    Piro, Maria Cristina
    Browne, Gareth J.
    Agostini, Massimiliano
    Bernardini, Sergio
    Knight, Richard A.
    Mak, Tak W.
    Melino, Gerry
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (29) : 12877 - 12882
  • [32] Analysis of the intracellular localization of p73 N-terminal protein isoforms TAp73 and ∆Np73 in medulloblastoma cell lines
    Marta Nekulová
    Karel Zitterbart
    Jaroslav Štěrba
    Renata Veselská
    Journal of Molecular Histology, 2010, 41 : 267 - 275
  • [33] Analysis of the intracellular localization of p73 N-terminal protein isoforms TAp73 and ΔNp73 in medulloblastoma cell lines
    Nekulova, Marta
    Zitterbart, Karel
    Sterba, Jaroslav
    Veselska, Renata
    JOURNAL OF MOLECULAR HISTOLOGY, 2010, 41 (4-5) : 267 - 275
  • [34] The expression of PTEN tumor suppressor is downregulated by the dominant negative P73 isoform ΔNp73 in thyroid cancer cells
    Vella, V.
    Puppin, C.
    Messina, L.
    Sanfilippo, M.
    Vigneri, R.
    Damante, G.
    Frasca, F.
    HORMONE RESEARCH, 2007, 68 : 38 - 38
  • [35] ΔNP73α inhibits PTEN expression in thyroid cancer cells
    Vella, Veronica
    Puppin, Cinzia
    Damante, Giuseppe
    Vigneri, Riccardo
    Sanfilippo, Mariangela
    Vigneri, Paolo
    Tell, Gianluca
    Frasca, Francesco
    INTERNATIONAL JOURNAL OF CANCER, 2009, 124 (11) : 2539 - 2548
  • [36] ΔNp73, TAp73 and Δ133p53 Extracellular Vesicle Cargo as Early Diagnosis Markers in Colorectal Cancer
    Rodriguez-Cobos, Javier
    Vinal, David
    Poves, Carmen
    Fernandez-Acenero, Maria J.
    Peinado, Hector
    Pastor-Morate, Daniel
    Prieto, M. Isabel
    Barderas, Rodrigo
    Rodriguez-Salas, Nuria
    Dominguez, Gemma
    CANCERS, 2021, 13 (09)
  • [37] Clinical Relevance of TAp73 and ΔNp73 Protein Expression in Ovarian Cancer: A Series of 83 Cases and Review of the Literature (vol 30, pg 527, 2011)
    Zeimet, A. G.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2012, 31 (03) : 296 - 296
  • [38] Clinical Relevance of TAp73 and ΔNp73 Protein Expression in Ovarian Cancer: A Series of 83 Cases and Review of the Literature (vol 30, pg 527, 2011)
    Zeimet A., G.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2012, 31 (02) : 199 - 199
  • [39] Disruption of chromosomal locus 1p36 differentially modulates TAp73 and ΔNp73 expression and aggressiveness in non-Hodgkin's lymphoma
    Hassan, Hesham M.
    Varney, Michelle L.
    Jain, Smrati
    Weisenburger, Dennis D.
    Singh, Rakesh K.
    Dave, Bhavana J.
    CANCER RESEARCH, 2011, 71
  • [40] TAp73 and ΔNp73 Have Opposing Roles in 5-aza-2′-Deoxycytidine-Induced Apoptosis in Breast Cancer Cells
    Lai, Jing
    Yang, Fang
    Zhang, Wenwen
    Wang, Yanru
    Xu, Jing
    Song, Wei
    Huang, Guichun
    Gu, Jun
    Guan, Xiaoxiang
    MOLECULES AND CELLS, 2014, 37 (08) : 605 - 612
12345