Expression of TAp73 and ΔNp73 isoform transcripts in thyroid tumours

被引：13
|
作者：
Ferru, A
Denis, S
Guilhot, J
Gibelin, H
Tourani, JM
Kraimps, JL
Larsen, CJ
Karayan-Tapon, L
机构：
[1] PBS, EA3805, Mol Oncol Lab, F-86021 Poitiers, France
[2] CHU La Miletrie, Med Oncol Serv, F-86021 Poitiers, France
[3] CHU La Miletrie, Ctr Rech Clin, F-86021 Poitiers, France
[4] CHU La Miletrie, Serv Chirurg Viscerale & Endocrinienne, F-86021 Poitiers, France
来源：
EJSO | 2006年 / 32卷 / 02期
关键词：
thyroid; carcinoma; transcripts; TAp73; Delta Np73;
D O I：
10.1016/j.ejso.2005.09.014
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: This study was aimed to determine p73 status in thyroid tumours. Methods: Differential expression of the TAp73, Delta TAp73 transcripts was measured in a panel of 60 thyroid malignancies by quantitative RTPCR. Results: By comparison to normal thyroid tissue surrounding the tumours, we observed significant downregulation of TP73 transcripts in adenomas and in differentiated carcinomas. Correlations were found in normal tissue specimens between the expression of TAp73 and Delta Np73 transcripts and that of p53, p14(ARF) p16(INK4a), but these correlations were lost in carcinomas (PTC or FTC). Conclusions: We have found significant variations of TAp73, Delta Np73, p53, p14(ARF) p16(INK4a), expressions and correlations between the expressions of those different genes in thyroid cancer. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：228 / 230
页数：3
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