Discovery of exceptionally efficient catalysts for solvent-free enantioselective hetero-Diels-Alder reaction

被引：187
|
作者：
Long, J [1 ]
Hu, JY [1 ]
Shen, XQ [1 ]
Ji, BM [1 ]
Ding, KL [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 01期
关键词：
D O I：
10.1021/ja0172518
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Combinatorial coordination chemistry strategy combined with high-throughput screening techniques has been successfully applied to engineering practical enantioselective catalysts for asymmetric hetero-Diels-Alder reaction. The reaction of Danishefsky's diene with a variety of aldehydes can be carried out with 0.1-0.005 mol % of H4-BINOL/Ti/H4-BINOL or H4-BINOL/Ti/H8-BINOL catalysts at room temperature under solvent- and MS-free conditions to afford dihydropyrone derivatives with up to quantitative yield and 99.8% ee. Copyright © 2002 American Chemical Society.
引用
收藏
页码：10 / 11
页数：2
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