Enantioselective Hetero-Diels-Alder Reaction and the Synthesis of Spiropyrrolidone Derivatives

被引：13

作者：

Huang, Yekai

Li, Yanan

Sun, Jianan

Li, Jindong

Zha, Zhenggen ^{[1
]}

Wang, Zhiyong ^{[1
]}

机构：

[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 15期

基金：

中国国家自然科学基金;

关键词：

BETA; GAMMA-UNSATURATED ALPHA-KETOESTERS; DANISHEFSKYS DIENE; CARBONYL-COMPOUNDS; GLYOXYLATE ESTERS; HENRY REACTION; ACID CATALYST; ALDEHYDES; COMPLEX; CYCLOPENTADIENE; CYCLOADDITION;

D O I：

10.1021/acs.joc.8b01057

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient enantioselective hetero-Diels-Alder reaction was developed under catalysis of a chiral copper complex. A variety of spiropyrrolidones, which bear a tetra-substituted carbon stereocenter, can be obtained in good yields with excellent enantioselectivities by virtue of this method. Furthermore, a substrate-dependent reaction pathway was proposed on the basis of the isolated intermediates.

引用

页码：8464 / 8472

页数：9

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