Rapid chemical space exploration in batch and flow: Applications from discovery to manufacturing

被引：0
|
作者：
Sach, Neal William [1 ]
机构：
[1] Pfizer Inc, Med Chem, San Diego, CA 92121 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 244卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
702-ORGN
引用
收藏
页数：1
相关论文
共 50 条
  • [41] Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core
    Sivaprakasam, Prasanna
    Han, Xiaojun
    Civiello, Rita L.
    Jacutin-Porte, Swanee
    Kish, Kevin
    Pokross, Matt
    Lewis, Hal A.
    Ahmed, Nazia
    Szapiel, Nicolas
    Newitt, John A.
    Baldwin, Eric T.
    Xiao, Hong
    Krause, Carol M.
    Park, Hyunsoo
    Nophsker, Michelle
    Lippy, Jonathan S.
    Burton, Catherine R.
    Langley, David R.
    Macor, John E.
    Dubowchik, Gene M.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (09) : 1856 - 1863
  • [42] Exploration of rapid start-up of the CANON process from activated sludge inoculum in a sequencing biofilm batch reactor (SBBR)
    Deng, Yangfan
    Zhang, Xiaoling
    Miao, Ying
    Hu, Bo
    WATER SCIENCE AND TECHNOLOGY, 2016, 73 (03) : 535 - 542
  • [43] Rapid access to unexplored chemical space by ligand scanning around a ruthenium center: Discovery of potent and selective protein kinase inhibitors
    Bregman, H
    Carroll, PJ
    Meggers, E
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (03) : 877 - 884
  • [44] Rapid access to unexplored chemical space by ligand scanning around a ruthenium center: Discovery of potent and selective protein kinase inhibitors
    Bregman, Howard
    Carroll, Patrick J.
    Meggers, Eric
    Journal of the American Chemical Society, 2006, 128 (03): : 877 - 884
  • [45] Keynote Lecture "Strategies to prioritize the discovery of bioactive natural products - Chemical space exploration based on massive multi-informative metabolite networks"
    Wolfender, J-L
    Gaudry, A.
    Quiros-Guerrero, L.
    Kirchhoffer, O.
    Rutz, A.
    Marcourt, L.
    David, B.
    Grondin, A.
    Nothias, L-F
    Ferreira, Queiroz E.
    Allard, P. M.
    PLANTA MEDICA, 2022, 88 (15) : 1403 - 1403
  • [46] The powered resonance tube: From Hartmann's discovery to current active flow control applications
    Raman, Ganesh
    Srinivasan, K.
    PROGRESS IN AEROSPACE SCIENCES, 2009, 45 (4-5) : 97 - 123
  • [47] Oxidative Neutralisation of Sulfur-Based Chemical Warfare Agents Mediated by a Lipase: From Batch to Flow Reactor
    Boddaert, Maxime
    da Silva, Valmir Baptista
    Mansour, Sergui
    Vuluga, Daniela
    Renard, Pierre-Yves
    Monbaliu, Jean-Christophe M.
    Legros, Julien
    CHEMISTRY-A EUROPEAN JOURNAL, 2025, 31 (19)
  • [48] Evidence for rapid fluid flow from the subarachnoid space into the spinal cord central canal in the rat
    Stoodley, MA
    Jones, NR
    Brown, CJ
    BRAIN RESEARCH, 1996, 707 (02) : 155 - 164
  • [49] Stabilisation of condensate flow from curvilinear surfaces by means of porous media for space applications
    Barakhovskaia, Ella
    Glushchuk, Andrey
    Queeckers, Patrick
    Iorio, Carlo S.
    EXPERIMENTAL THERMAL AND FLUID SCIENCE, 2021, 121
  • [50] Innovation pathways in additive manufacturing: Methods for tracing emerging and branching paths from rapid prototyping to alternative applications
    Robinson, Douglas K. R.
    Lagnau, Axel
    Boon, Wouter P. C.
    TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE, 2019, 146 : 733 - 750
12345