SC-2001, a SHP-1 enhancer, induces apoptosis in hepatocellular carcinoma through SHP-1 dependent STAT3 inactivation

被引:0
|
作者
Chen, Kuen-Feng [1 ]
Su, Jung-Chen [2 ]
Chen, Wei-Lin [2 ]
Liu, Chun-Yu [3 ]
Cheng, Ann-Lii [4 ]
Chen, Pel-Jer [1 ]
Shiau, Chung-Wai [2 ]
机构
[1] Natl Taiwan Univ Hosp, Dept Med Res, Taipei, Taiwan
[2] Natl Yang Ming Univ, Inst Biopharmaceut Sci, Taipei 112, Taiwan
[3] Taipei Vet Gen Hosp, Dept Internal Med, Div Hematol & Oncol, Taipei, Taiwan
[4] Natl Taiwan Univ Hosp, Dept Oncol, Taipei, Taiwan
关键词
D O I
10.1158/1538-7445.AM2011-4516
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4516
引用
收藏
页数:1
相关论文
共 50 条
  • [21] A novel imidazole derivate inhibits STAT3 activation via induction of SHP-1 hepatocellular carcinoma
    Su, Jung-Chen
    Wu, Szu-Hsien
    Chen, Kuen-Feng
    Tai, Wei-Tien
    Huang, Jui-Wen
    Shiau, Chung-Wai
    CANCER RESEARCH, 2014, 74 (19)
  • [22] Constitutive activation of STAT3 in Sezary syndrome is independent of SHP-1
    McKenzie, R. C. T.
    Jones, C. L.
    Tosi, I.
    Caesar, J. A.
    Whittaker, S. J.
    Mitchell, T. J.
    LEUKEMIA, 2012, 26 (02) : 323 - 331
  • [23] Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1
    Su, Jung-Chen
    Chang, Chuan-Hsun
    Wu, Szu-Hsien
    Shiau, Chung-Wai
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2018, 33 (01) : 1248 - 1255
  • [24] A sorafenib derivative and novel SHP-1 agonist, SC-59, acts synergistically with radiotherapy in hepatocellular carcinoma cells through inhibition of STAT3
    Huang, C. Y.
    Tai, W. T.
    Hsieh, C. Y.
    Lai, Y. J.
    Hsu, W. M.
    Chen, L. J.
    Shiau, C. W.
    Chen, K. F.
    EUROPEAN JOURNAL OF CANCER, 2014, 50 : S174 - S174
  • [25] A sorafenib derivative and novel SHP-1 agonist, SC-59, acts synergistically with radiotherapy in hepatocellular carcinoma cells through inhibition of STAT3
    Huang, Chao-Yuan
    Tai, Wei-Tien
    Hsieh, Chi-Ying
    Hsu, Wan-Mai
    Lai, Ying-Jiun
    Chen, Li-Ju
    Shiau, Chung-Wai
    Chen, Kuen-Feng
    CANCER LETTERS, 2014, 349 (02) : 136 - 143
  • [26] Constitutive activation of STAT3 in Sézary syndrome is independent of SHP-1
    R C T McKenzie
    C L Jones
    I Tosi
    J A Caesar
    S J Whittaker
    T J Mitchell
    Leukemia, 2012, 26 : 323 - 331
  • [27] Inhibition of STAT3 in gastric cancer: role of pantoprazole as SHP-1 inducer
    Koh, Jin Sung
    Joo, Moon Kyung
    Park, Jong-Jae
    Yoo, Hyo Soon
    Choi, Byung Il
    Lee, Beom Jae
    Chun, Hoon Jai
    Lee, Sang Woo
    CELL AND BIOSCIENCE, 2018, 8
  • [28] Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity
    Chen, Kuen-Feng
    Tai, Wei-Tien
    Hsu, Cheng-Yi
    Huang, Jui-Wen
    Liu, Chun-Yu
    Chen, Pei-Jer
    Kim, InKi
    Shiau, Chung-Wai
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 : 220 - 227
  • [29] Inhibition of STAT3 in gastric cancer: role of pantoprazole as SHP-1 inducer
    Jin Sung Koh
    Moon Kyung Joo
    Jong-Jae Park
    Hyo Soon Yoo
    Byung Il Choi
    Beom Jae Lee
    Hoon Jai Chun
    Sang Woo Lee
    Cell & Bioscience, 8
  • [30] Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases
    Lee, Jong Hyun
    Chiang, Shu Yuan
    Nam, Dongwoo
    Chung, Won-Seok
    Lee, Junhee
    Na, Young-Soon
    Sethi, Gautam
    Ahn, Kwang Seok
    CANCER LETTERS, 2014, 345 (01) : 140 - 148