Effect of EDA/PEGDGE mole ratios on PEG-based Hydrogel Scaffolds Properties

被引：3

作者：

Hamid, Zuratul Ain Abdul ^{[1
]}

Blencowe, Anton ^{[2
]}

Qiao, Greg ^{[2
]}

Stevens, Geoff ^{[2
]}

机构：

[1] Univ Sains Malaysia, Sch Mat & Mineral Resources Engn, Engn Campus,14300 Nibong Tebal, Pulau, Pinang, Malaysia

[2] Univ Melbourne, Dept Chem & Biomol Engn, Victoria 3010, Australia

来源：

ADVANCED MATERIALS ENGINEERING AND TECHNOLOGY | 2012年 / 626卷

关键词：

hydrogel scaffolds; epoxy-amine step growth polymerization; tissue engineering; cross-linked hydrogel; TISSUE-ENGINEERING APPLICATIONS; POLY(ETHYLENE GLYCOL); BIODEGRADABLE HYDROGELS; POLYETHYLENE-GLYCOL; COPOLYMERS;

D O I：

10.4028/www.scientific.net/AMR.626.681

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The synthesis of biocompatible hydrogel based on poly(ethylene glycol) (PEG) and ethylene diamine (EDA) using epoxy-amine chemistry was conducted. PEG was chosen as the base material (or monomer) to synthesise hydrogels in this study due to its high hydrophilicity, biocompatibility and low toxicity properties. The effects of mole ratios of EDA to PEGDGE on the hydrogel scaffolds properties (i.e., gelling time, swelling) were investigated. It was found out for hydrogel scaffolds prepared at 1.2 and 1.4 M [PEGDGE] and an EDA/PEGDGE mol ratio of 0.5 in DMSO gave the optimum hydrogel properties. Swelling studies has confirmed that hydrogel prepared at 0.5 mole ratios consist of highly cross-linked network as expected.

引用

页码：681 / +

页数：2

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