This study presents sulfide ores with lead 0.71%, Zinc5.07% from Laos, using a grinding (grinding fineness -0.075mm, 80%). Then, the lead ores is recovered by flotation first. Second, the middling ores is returned in preferential floatation. The mixed collector is used in all flotation such as ethyl xanthogenate, butyl xanthate and SN-9.After flotation, the grade of lead concentrate is 63.63%, and a recovery is 83.26% .In addition, the grade of zinc is 56.33%,a recovery is 86.63%. It can result in obvious increase in yields of mineral processing and economic better effect in production, compared to the old technology.