Comparative Prospective and Longitudinal Analysis on the Platelet-to-Lymphocyte, Neutrophil-to-Lymphocyte, and Albumin-to-Globulin Ratio in Patients with Non-Metastatic and Metastatic Prostate Cancer

被引:8
|
作者
Salciccia, Stefano [1 ]
Frisenda, Marco [1 ]
Bevilacqua, Giulio [1 ]
Viscuso, Pietro [1 ]
Casale, Paolo [2 ]
De Berardinis, Ettore [1 ]
Di Pierro, Giovanni Battista [1 ]
Cattarino, Susanna [1 ]
Giorgino, Gloria [1 ]
Rosati, Davide [1 ]
Del Giudice, Francesco [1 ]
Carbone, Antonio [3 ]
Pastore, Antonio [3 ]
Chung, Benjamin I. I. [4 ]
Eisenberg, Michael L. L. [4 ]
Autorino, Riccardo [5 ]
Crivellaro, Simone [6 ]
Forte, Flavio [7 ]
Sciarra, Alessandro [1 ]
Mariotti, Gianna [1 ]
Gentilucci, Alessandro [1 ]
机构
[1] Sapienza Univ Rome, Policlin Umberto Hosp 1, Dept Materno Infantile & Sci Urolog, I-00161 Rome, Italy
[2] Humanitas, Dept Urol, I-20089 Milan, Italy
[3] Sapienza Univ, ICOT Hosp Latina, Unit Urol, I-04100 Latina, Italy
[4] Stanford Univ, Sch Med, Dept Urol, Stanford, CA 94305 USA
[5] Rush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
[6] Univ Illinois, Hosp Camp, Dept Urol, Hlth Sci Syst, Chicago, IL 60612 USA
[7] MG Vannini Hosp, Urol Dept, I-00177 Rome, Italy
关键词
albumin-to-globulin ratio; neutrophil-to-lymphocyte ratio; metastatic; platelet-to-lymphocyte ratio; prostatic neoplasm; radical prostatectomy; PRETREATMENT ALBUMIN; PROGNOSTIC VALUE; NODE DISSECTION;
D O I
10.3390/curroncol29120745
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: To prospectively evaluate the albumin/globulin ratio (AGR), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) diagnostic and prognostic predictive value in a stratified population of prostate cancer (PC) cases. Methods: Population was divided based on the clinical and histologic diagnosis in: Group A: benign prostatic hyperplasia (BPH) cases (494 cases); Group B: all PC cases (525 cases); Group B1: clinically significant PC (426 cases); Group B2: non-metastatic PC (416 cases); Group B3: metastatic PC (109 cases). NLR, PLR, and AGR were obtained at the time of the diagnosis, and only in cases with PC considered for radical prostatectomy, determinations were also repeated 90 days after surgery. For each ratio, cut-off values were determined by receiver operating characteristics curve (ROC) analysis and fixed at 2.5, 120.0, and 1.4, respectively, for NLR, PLR, and AGR. Results: Accuracy in predictive value for an initial diagnosis of clinically significant PC (csPC) was higher using PLR (0.718) when compared to NLR (0.220) and AGR (0.247), but, despite high sensitivity (0.849), very low specificity (0.256) was present. The risk of csPC significantly increased only according to PLR with an OR = 1.646. The percentage of cases with metastatic PC significantly increased according to high NLR and high PLR. Accuracy was 0.916 and 0.813, respectively, for NLR and PLR cut-off, with higher specificity than sensitivity. The risk of a metastatic disease increased 3.2 times for an NLR > 2.5 and 5.2 times for a PLR > 120 and at the multivariate analysis. Conclusion: PLR and NLR have a significant predictive value towards the development of metastatic disease but not in relation to variations in aggressiveness or T staging inside the non-metastatic PC. Our results suggest an unlikely introduction of these analyses into clinical practice in support of validated PC risk predictors.
引用
收藏
页码:9474 / 9500
页数:27
相关论文
共 50 条
  • [21] Assessment of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with high myopia
    Xin Wang
    Qing He
    Xiaoyu Zhao
    Haoru Li
    Lin Liu
    Di Wu
    Ruihua Wei
    BMC Ophthalmology, 22
  • [22] Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in Patients with Retinal Artery Occlusion
    Atum, Mahmut
    Alagoz, Gursoy
    JOURNAL OF OPHTHALMIC & VISION RESEARCH, 2020, 15 (02) : 195 - 200
  • [23] Assessment of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with high myopia
    Wang, Xin
    He, Qing
    Zhao, Xiaoyu
    Li, Haoru
    Liu, Lin
    Wu, Di
    Wei, Ruihua
    BMC OPHTHALMOLOGY, 2022, 22 (01)
  • [24] Association of Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio with the Risk of Thromboembolism and Mortality in Patients with Cancer
    Grilz, Ella
    Posch, Florian
    Koenigsbruegge, Oliver
    Schwarzinger, Ilse
    Lang, Irene Marthe
    Marosi, Christine
    Pabinger, Ingrid
    Ay, Cihan
    THROMBOSIS AND HAEMOSTASIS, 2018, 118 (11) : 1875 - 1884
  • [25] Prognostic significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with stage Ⅲ and Ⅳ colorectal cancer
    Jae Hyun Kim
    Jun Yeop Lee
    Hae Koo Kim
    Jin Wook Lee
    Sung Gyu Jung
    Kyoungwon Jung
    Sung Eun Kim
    Won Moon
    Moo In Park
    Seun Ja Park
    World Journal of Gastroenterology, 2017, (03) : 505 - 515
  • [26] Pretreatment neutrophil-to-lymphocyte ratio predicts the prognosis in patients with metastatic prostate cancer
    Kawahara, Takashi
    Yokomizo, Yumiko
    Ito, Yusuke
    Ito, Hiroki
    Ishiguro, Hitoshi
    Teranishi, Jun-ichi
    Makiyama, Kazuhide
    Miyoshi, Yasuhide
    Miyamoto, Hiroshi
    Yao, Masahiro
    Uemura, Hiroji
    BMC CANCER, 2016, 16
  • [27] The diagnostic and prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on gastric cancer patients
    Nguyen, Mai Ly Thi
    Pham, Chi
    Le, Quoc Vuong
    Nham, Phuong Linh Thi
    Tran, Doanh Hieu
    Le, Thanh Son
    Hoang, Van Tong
    Can, Van Mao
    Nguyen, Linh Toan
    Bui, Khac Cuong
    MEDICINE, 2023, 102 (31) : E34357
  • [28] Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio among Patients with Vestibular Neuritis
    Shushan, Sagit
    Shemesh, Shay
    Ungar, Omer J.
    Cavel, Oren
    Handzel, Ophir
    Tamir, Sharon Ovnat
    Oron, Yahav
    ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY, 2019, 81 (5-6): : 304 - 308
  • [29] Pretreatment neutrophil-to-lymphocyte ratio predicts the prognosis in patients with metastatic prostate cancer
    Takashi Kawahara
    Yumiko Yokomizo
    Yusuke Ito
    Hiroki Ito
    Hitoshi Ishiguro
    Jun-ichi Teranishi
    Kazuhide Makiyama
    Yasuhide Miyoshi
    Hiroshi Miyamoto
    Masahiro Yao
    Hiroji Uemura
    BMC Cancer, 16
  • [30] Neutrophil-to-lymphocyte ratio or platelet-to-lymphocyte ratio as prognostic biomarkers in patients with metastatic breast cancer treated with CDK4/6 inhibitors
    Weiner, Ashley
    Munoz-Arcos, Laura S.
    Ko, Heidi
    Anampa, Jesus
    CANCER RESEARCH, 2021, 81 (04)