Catalytic Enantioselective Friedel-Crafts Alkylation of Indoles with Fumarate Derivatives in the Presence of Chiral Palladium Complexes

被引：23

作者：

Lee, Hyun Joo ^{[1
]}

Kim, Dae Young ^{[1
]}

机构：

[1] Soonchunhyang Univ, Dept Chem, Asan 336745, Chungnam, South Korea

来源：

SYNLETT | 2012年 / 11期

关键词：

Friedel-Crafts reaction; asymmetric catalysis; chiral palladium catalysts; indoles; fumamate derivatives; MANNICH-TYPE REACTIONS; BETA-KETO-ESTERS; CONJUGATE ADDITION; ALPHA; BETA-UNSATURATED KETONES; CARBONYL-COMPOUNDS; ACID CATALYSIS; ASYMMETRIC-SYNTHESIS; ALPHA-HYDROXYLATION; MICHAEL ADDITION; PHOSPHORIC-ACID;

D O I：

10.1055/s-0031-1290424

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The catalytic enantioselective Friedel-Crafts alkylation reaction promoted by chiral palladium complexes is described. The treatment of indoles with fumarate derivatives under the mild reaction conditions afforded the corresponding Friedel-Crafts alkylation adducts with high enantioselectivities (up to 91% ee).

引用

页码：1629 / 1632

页数：4

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