Catalytic Enantioselective Friedel-Crafts Alkylation of Indoles with Fumarate Derivatives in the Presence of Chiral Palladium Complexes

被引：23
|
作者：
Lee, Hyun Joo [1 ]
Kim, Dae Young [1 ]
机构：
[1] Soonchunhyang Univ, Dept Chem, Asan 336745, Chungnam, South Korea
来源：
SYNLETT | 2012年 / 11期
关键词：
Friedel-Crafts reaction; asymmetric catalysis; chiral palladium catalysts; indoles; fumamate derivatives; MANNICH-TYPE REACTIONS; BETA-KETO-ESTERS; CONJUGATE ADDITION; ALPHA; BETA-UNSATURATED KETONES; CARBONYL-COMPOUNDS; ACID CATALYSIS; ASYMMETRIC-SYNTHESIS; ALPHA-HYDROXYLATION; MICHAEL ADDITION; PHOSPHORIC-ACID;
D O I：
10.1055/s-0031-1290424
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The catalytic enantioselective Friedel-Crafts alkylation reaction promoted by chiral palladium complexes is described. The treatment of indoles with fumarate derivatives under the mild reaction conditions afforded the corresponding Friedel-Crafts alkylation adducts with high enantioselectivities (up to 91% ee).
引用
收藏
页码：1629 / 1632
页数：4
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