A case of leukemia cutis presenting as histiocytoid Sweet's syndrome

Background Leukemia cutis (LC) represents a skin infiltration by leukemic cells. Clinically, it can mimic a wide variety of dermatoses. Methods We report a case of LC presenting with a Sweet's syndrome-like eruption and a histiocytoid Sweet's syndrome histologic manifestation. Results This case may represent distinct and important cutaneous and histopathologic manifestations of LC. Conclusions We believe that peripheral blood or bone marrow cytologic analysis is necessary in cases of LC to rule out the possibility of histiocytoid Sweet's syndrome. Additional study is needed to further elucidate the relationship between LC and histiocytoid Sweet's syndrome.