Synthesis of uridine analogues to probe the functional group requirements of the hairpin ribozyme

被引：0
|
作者：
Vyle, JS
Young, KJ
Jones, S
Grasby, JA
机构：
来源：
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1996年 / 61卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
O-4-Methyluridine, O-2-methyluridine and (4H)uridine phosphoramidites were prepared with 2'-O-silyl protection, The methyl modified pyrimidines were synthesised from uridine via the triazolide (O-4-methyl) or 2,5'-cyclo derivative (O-2-methyl). An improved synthesis of protected 4-thiouridine was also performed.
引用
收藏
页码：S280 / S282
页数：3
相关论文
共 50 条
  • [1] Functional group mutagenesis of the hairpin ribozyme
    McDonald, IK
    Holmes, SC
    Young, KJ
    Vyle, JS
    Pickering, TJ
    Grasby, JA
    CHEMISTRY OF NUCLEIC ACID COMPONENTS, 1999, 2 : 306 - 309
  • [2] Functional equivalence of the uridine turn and the hairpin as building blocks of tertiary structure in the Neurospora VS ribozyme
    Sood, VD
    Collins, RA
    JOURNAL OF MOLECULAR BIOLOGY, 2001, 313 (05) : 1013 - 1019
  • [3] Functional group requirements in the probable active site of the VS ribozyme
    Lafontaine, DA
    Wilson, TJ
    Zhao, ZY
    Lilley, DMJ
    JOURNAL OF MOLECULAR BIOLOGY, 2002, 323 (01) : 23 - 34
  • [4] Specificity of the Hairpin Ribozyme: Sequence Requirements Surrounding the Cleavage Site
    Perez-Ruiz, Mercedes
    Barroso-DelJesus, Alicia
    Berzal-Herranz, Alfredo
    Journal of Biological Chemistry, 274 (41): : 29376 - 29380
  • [5] Specificity of the hairpin ribozyme -: Sequence requirements surrounding the cleavage site
    Pérez-Ruiz, M
    Barroso-delJesus, A
    Berzal-Herranz, A
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (41) : 29376 - 29380
  • [6] Functional analysis of hairpin ribozyme active site architecture
    Cottrell, Joseph W.
    Kuzmin, Yaroslav I.
    Fedor, Martha J.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (18) : 13498 - 13507
  • [7] IONIC REQUIREMENTS FOR RNA-BINDING, CLEAVAGE, AND LIGATION BY THE HAIRPIN RIBOZYME
    CHOWRIRA, BM
    BERZALHERRANZ, A
    BURKE, JM
    BIOCHEMISTRY, 1993, 32 (04) : 1088 - 1095
  • [8] LOOP-SIZE VARIATION TO PROBE A BENT STRUCTURE OF A HAIRPIN RIBOZYME
    KOMATSU, Y
    KOIZUMI, M
    NAKAMURA, H
    OHTSUKA, E
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (09) : 3692 - 3696
  • [9] Loop-size variation to probe a bent structure of a hairpin ribozyme
    1600, (116):
  • [10] RECONSTITUTION OF HAIRPIN RIBOZYME ACTIVITY FOLLOWING SEPARATION OF FUNCTIONAL DOMAINS
    BUTCHER, SE
    HECKMAN, JE
    BURKE, JM
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (50) : 29648 - 29651
12345