Synthesis of new 3,4-disubstituted pyrrolidines as thromboxane A(2) prostaglandin H-2 (TP) receptor antagonists

被引：33

作者：

Dubuffet, T ^{[1
]}

Muller, O ^{[1
]}

Simonet, SS ^{[1
]}

Descombes, JJ ^{[1
]}

Laubie, M ^{[1
]}

Verbeuren, TJ ^{[1
]}

Lavielle, G ^{[1
]}

机构：

[1] INST RECH SERVIER,F-92150 SURESNES,FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 04期

关键词：

D O I：

10.1016/0960-894X(96)00021-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and TP-receptor antagonistic activity of a series of 3,4-disubstituted pyrrolidines is described. The sulfonamide 1h was the most potent TP-receptor antagonist in this series with a pA(2) value of 9.5 in isolated guinea pig trachea.

引用

页码：349 / 352

页数：4

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