Changing the metabolism of cancer cells with PKM2 activators - a path to a cancer metabolism drug

被引：0
|
作者：
Behar, Vered [1 ]
Bohana-Kashtan, Osnat [1 ]
Shitrit, Alina [1 ]
Ben-Zeev, Efrat [1 ]
Konson, Alexander [1 ]
Ozeri, Rachel [1 ]
Kehat, Tzofit [1 ]
Mirilashvili, Sima [1 ]
Schutz, Nili C. [1 ]
Yacovan, Avihai [1 ]
Becker, Oren M. [1 ]
机构：
[1] Dynamix Pharmaceut Ltd, Rehovot, Israel
来源：
CANCER RESEARCH | 2012年 / 72卷
关键词：
D O I：
10.1158/1538-7445.AM2012-3219
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
3219
引用
收藏
页数：2
相关论文
共 50 条
  • [41] The responsively decreased PKM2 facilitates the survival of pancreatic cancer cells in hypoglucose
    Li, Xiang
    Deng, Shichang
    Liu, Mingliang
    Jin, Yan
    Zhu, Shuai
    Deng, Shijiang
    Chen, Jingyuan
    He, Chi
    Qin, Qi
    Wang, Chunyou
    Zhao, Gang
    CELL DEATH & DISEASE, 2018, 9
  • [42] Mutant p53 and mTOR/PKM2 regulation in cancer cells
    Dando, Ilaria
    Cordani, Marco
    Donadelli, Massimo
    IUBMB LIFE, 2016, 68 (09) : 722 - 726
  • [43] PKM2 Is Essential for Bladder Cancer Growth and Maintenance
    Xia, Yong
    Wang, Xing
    Liu, Yan
    Shapiro, Ellen
    Lepor, Herbert
    Tang, Moon-shong
    Sun, Tung-Tien
    Wu, Xue-Ru
    CANCER RESEARCH, 2022, 82 (04) : 571 - 585
  • [44] PKM2 and the Tricky Balance of Growth and Energy in Cancer
    Macintyre, Andrew N.
    Rathmell, Jeffrey C.
    MOLECULAR CELL, 2011, 42 (06) : 713 - 714
  • [45] Changes in PKM2 Associate with Prostate Cancer Progression
    Wong, Nicholas
    Yan, Judy
    Ojo, Diane
    De Melo, Jason
    Cutz, Jean-Claude
    Tang, Damu
    CANCER INVESTIGATION, 2014, 32 (07) : 330 - 338
  • [46] The Role of PKM2 in the Regulation of Mitochondrial Function: Focus on Mitochondrial Metabolism, Oxidative Stress, Dynamic, and Apoptosis. PKM2 in Mitochondrial Function
    Gao, Jing
    Zhao, Yuwei
    Li, Tao
    Gan, Xueqi
    Yu, Haiyang
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2022, 2022
  • [47] MYC and metabolism on the path to cancer
    Hsieh, Annie L.
    Walton, Zandra E.
    Altman, Brian J.
    Stine, Zachary E.
    Dang, Chi V.
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2015, 43 : 11 - 21
  • [48] Sanguinarine Induces Necroptosis of HCC by Targeting PKM2 Mediated Energy Metabolism
    Kong, Rui
    Wang, Nan
    Zhou, Chunli
    Zhou, Yuqing
    Guo, Xiaoyan
    Wang, Dongyan
    Shi, Yihai
    Wan, Rong
    Zheng, Yuejuan
    Lu, Jie
    CANCERS, 2024, 16 (14)
  • [49] PKM2 is not required for colon cancer initiated by APC loss
    Allison N. Lau
    William J. Israelsen
    Jatin Roper
    Mark J. Sinnamon
    Larissa Georgeon
    Talya L. Dayton
    Alissandra L. Hillis
    Omer H. Yilmaz
    Dolores Di Vizio
    Kenneth E. Hung
    Matthew G. Vander Heiden
    Cancer & Metabolism, 5
  • [50] Emerging Roles of ncRNAs Regulating PKM2 in Cancer Progression
    Xie, Haimei
    Yu, Jia
    Ou, Zhiwen
    Lei, Xiaoyong
    Yang, Xiaoyan
    CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2024,
12345