Gut bacteria and cancer

被引：45
|
作者：
Erdman, Susan E. [1 ]
Poutahidis, Theofilos [1 ,2 ]
机构：
[1] MIT, Div Comparat Med, Cambridge, MA 02139 USA
[2] Aristotle Univ Thessaloniki, Fac Vet Med, Pathol Lab, Thessaloniki 54124, Greece
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2015年 / 1856卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Enteric; Microbes; Breast cancer; Mammary cancer; Immune system; Neutrophils; Regulatory T cells; REGULATORY T-CELLS; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; GENETICALLY-ENGINEERED MICE; BREAST-CANCER; INTESTINAL MICROBIOTA; CONSENSUS REPORT; IMMUNE-RESPONSE; TUMOR-GROWTH; COLON-CANCER; MOUSE MODEL;
D O I：
10.1016/j.bbcan.2015.05.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Microbiota on the mucosal surfaces of the gastrointestinal (GI) tract greatly outnumbers the cells in the human body. Effects of antibiotics indicate that GI tract bacteria may be determining the fate of distal cancers. Recent data implicate dysregulated host responses to enteric bacteria leading to cancers in extra-intestinal sites. Together these findings point to novel anti-cancer strategies aimed at promoting GI tract homeostasis. (C) 2015 Published by Elsevier B.V.
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页码：86 / 90
页数：5
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