Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients

被引：107

作者：

Silva, JM ^{[1
]}

Dominguez, G ^{[1
]}

Villanueva, MJ ^{[1
]}

Gonzalez, R ^{[1
]}

Garcia, JM ^{[1
]}

Corbacho, C ^{[1
]}

Provencio, M ^{[1
]}

España, P ^{[1
]}

Bonilla, F ^{[1
]}

机构：

[1] Clin Puerta de Hierro, Dept Med Oncol, Madrid 28035, Spain

来源：

BRITISH JOURNAL OF CANCER | 1999年 / 80卷 / 08期

关键词：

p16(INK4a) gene; DNA methylation; breast cancer; plasma DNA; CpG islands;

D O I：

10.1038/sj.bjc.6690495

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hypermethylation of exon 1 of p16(INK4a) was examined in tumour and plasma DNA of a series of breast cancer patients. De novo methylation was observed in the tumours of eight patients (23%), and in plasma DNA in five (14%) of these eight patients. Our data show that de novo methylation of exon 1 of p16(INK4a) can be demonstrated in plasma DNA of breast cancer patients, a fact that provides additional evidence of the tumour-related origin of free plasma DNA in cancer patients.

引用

下载

页码：1262 / 1264

页数：3

共 50 条

[41] Different prognostic values of p15INK4b and p16INK4a gene methylation in multiple myeloma
Guillerm, GL
Depil, S
Wolowiec, D
Quesnel, B
HAEMATOLOGICA, 2003, 88 (04) : 476 - 478
[42] Prognostic significance of p16INK4a hypermethylation in non-small cell lung cancer is evident by quantitative DNA methylation analysis
Ota, Naohiro
Kawakami, Kazuyuki
Okuda, Toshiyuki
Takehara, Akira
Hiranuma, Chikashi
Oyama, Kaeko
Ota, Yasuhiko
Oda, Makoto
Watanabe, Go
ANTICANCER RESEARCH, 2006, 26 (5B) : 3729 - 3732
[43] Aberrant p16INK4A methylation: Relation to viral related chronic liver disease and hepatocellular carcinoma
El-Mougy, Fatma A.
Youssef, Mohammed M.
Omran, Dalia A.
Sharaf, SaharA.
El-Sayed, Hany H.
Rabie, Walaa A.
Mohamed, Elghobary A.
Elghobary, Hany A.
SOUTH ASIAN JOURNAL OF CANCER, 2014, 3 (01) : 1 - 4
[44] Inactivation of the p16INK4A gene by methylation is not a frequent event in sporadic ovarian carcinoma
Brown, I
Milner, BJ
Rooney, PH
Haites, NE
ONCOLOGY REPORTS, 2001, 8 (06) : 1359 - 1362
[45] Downregulation and Aberrant Promoter Methylation of p16INK4A: A Possible Novel Heritable Susceptibility Marker to Retinoblastoma
Indovina, Paola
Acquaviva, Antonio
De Falco, Giulia
Rizzo, Valeria
Onnis, Anna
Luzzi, Anna
Giorgi, Francesca
Hadjistilianou, Theodora
Toti, Paolo
Tomei, Valentina
Pentimalli, Francesca
Carugi, Alessandro
Giordano, Antonio
JOURNAL OF CELLULAR PHYSIOLOGY, 2010, 223 (01) : 143 - 150
[46] A microarray to analyze methylation patterns of p16Ink4a gene 5′-CpG islands
Hou, P
Ji, MJ
Liu, ZC
Shen, JY
Cheng, L
He, NY
Lu, ZH
CLINICAL BIOCHEMISTRY, 2003, 36 (03) : 197 - 202
[47] Analysis of promoter methylation and protein expression of the p16INK4A gene in hepatocellular carcinoma
Csepregi, Antal
Hoffmann, Juliane
Roecken, Christoph
Malfertheiner, Peter
Ebert, Matthias
HEPATOLOGY, 2006, 44 (04) : 510A - 510A
[48] Inactivation of p16INK4a expression in malignant mesothelioma by methylation
Wong, L
Zhou, J
Anderson, D
Kratzke, RA
LUNG CANCER, 2002, 38 (02) : 131 - 136
[49] Promoter methylation of p16INK4A, RASSF1A, and RAR2b genes in turner DNA from patients with breast cancer (BC) in correlation with clinical recurrence
Voyatzi, S.
Desiris, K.
Paikos, D. A.
Stergiou, E.
Geromichalos, G.
Pazaitou, K.
Kiziridou, A.
Stravoravdi, P.
Simbilidis, G.
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15)
[50] Detection of aberrant methylation of four genes in plasma DNA for the detection of breast cancer
Hoque, Mohammad O.
Feng, Qinghua
Toure, Papa
Dem, Amadou
Critchlow, Cathy W.
Hawes, Stephen E.
Wood, Troy
Jeronimo, Carmen
Rosenbaum, Eli
Stern, Joshua
Yu, Mujun
Trink, Barry
Kiviat, Nancy B.
Sidransky, David
JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (26) : 4262 - 4269

← 1 2 3 4 5 →