Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients

被引：107

作者：

Silva, JM ^{[1
]}

Dominguez, G ^{[1
]}

Villanueva, MJ ^{[1
]}

Gonzalez, R ^{[1
]}

Garcia, JM ^{[1
]}

Corbacho, C ^{[1
]}

Provencio, M ^{[1
]}

España, P ^{[1
]}

Bonilla, F ^{[1
]}

机构：

[1] Clin Puerta de Hierro, Dept Med Oncol, Madrid 28035, Spain

来源：

BRITISH JOURNAL OF CANCER | 1999年 / 80卷 / 08期

关键词：

p16(INK4a) gene; DNA methylation; breast cancer; plasma DNA; CpG islands;

D O I：

10.1038/sj.bjc.6690495

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hypermethylation of exon 1 of p16(INK4a) was examined in tumour and plasma DNA of a series of breast cancer patients. De novo methylation was observed in the tumours of eight patients (23%), and in plasma DNA in five (14%) of these eight patients. Our data show that de novo methylation of exon 1 of p16(INK4a) can be demonstrated in plasma DNA of breast cancer patients, a fact that provides additional evidence of the tumour-related origin of free plasma DNA in cancer patients.

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页码：1262 / 1264

页数：3

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